Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1179525..1179939 Replicon chromosome
Accession NZ_CP012018
Organism Staphylococcus aureus strain Gv88

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SAGV88_RS05940 Protein ID WP_052998299.1
Coordinates 1179525..1179776 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SAGV88_RS16480 Protein ID WP_000028423.1
Coordinates 1179766..1179939 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGV88_RS05880 1175055..1175825 + 771 WP_059283876.1 conserved phage C-terminal domain-containing protein -
SAGV88_RS05885 1175835..1176607 + 773 Protein_1137 ATP-binding protein -
SAGV88_RS16475 1176601..1176762 + 162 WP_000237153.1 hypothetical protein -
SAGV88_RS05895 1176775..1176996 + 222 WP_041205435.1 DUF3269 family protein -
SAGV88_RS05900 1177006..1177410 + 405 WP_020444760.1 DUF1064 domain-containing protein -
SAGV88_RS05905 1177415..1177600 + 186 WP_001187239.1 DUF3113 family protein -
SAGV88_RS05910 1177601..1177964 + 364 Protein_1142 hypothetical protein -
SAGV88_RS05915 1177964..1178218 + 255 WP_000022727.1 DUF3310 domain-containing protein -
SAGV88_RS05920 1178218..1178466 + 249 WP_072466103.1 hypothetical protein -
SAGV88_RS05925 1178479..1178883 + 405 WP_020444668.1 hypothetical protein -
SAGV88_RS05930 1178880..1179227 + 348 WP_000979209.1 hypothetical protein -
SAGV88_RS05935 1179224..1179532 + 309 WP_001668981.1 hypothetical protein -
SAGV88_RS05940 1179525..1179776 + 252 WP_052998299.1 DUF1024 family protein Toxin
SAGV88_RS16480 1179766..1179939 + 174 WP_000028423.1 hypothetical protein Antitoxin
SAGV88_RS16485 1179940..1180101 + 162 WP_000889680.1 hypothetical protein -
SAGV88_RS05945 1180116..1180649 + 534 WP_031790047.1 dUTPase -
SAGV88_RS05950 1180686..1180874 + 189 WP_000195793.1 DUF1381 domain-containing protein -
SAGV88_RS05955 1180849..1181049 + 201 WP_001125015.1 hypothetical protein -
SAGV88_RS05960 1181052..1181225 + 174 WP_001797333.1 transcriptional activator RinB -
SAGV88_RS05965 1181226..1181372 + 147 WP_000990002.1 hypothetical protein -
SAGV88_RS05970 1181387..1181806 + 420 WP_000058632.1 transcriptional regulator -
SAGV88_RS05975 1181994..1182434 + 441 WP_001003271.1 terminase small subunit -
SAGV88_RS05980 1182421..1183698 + 1278 WP_000169946.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1159975..1207884 47909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9418.28 Da        Isoelectric Point: 3.8146

>T55510 WP_052998299.1 NZ_CP012018:1179525-1179776 [Staphylococcus aureus]
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKRAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T55510 NZ_CP012018:1179525-1179776 [Staphylococcus aureus]
ATGGATAACCGCGAACAAATCGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGTTAAA
AGAGATTGAGGACGTGTATAAGAGAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6482.32 Da        Isoelectric Point: 4.2484

>AT55510 WP_000028423.1 NZ_CP012018:1179766-1179939 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSIISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT55510 NZ_CP012018:1179766-1179939 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAATTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References