Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2626030..2626547 Replicon chromosome
Accession NZ_CP012015
Organism Staphylococcus aureus strain Gv51

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAGV51_RS13625 Protein ID WP_000113262.1
Coordinates 2626030..2626296 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAGV51_RS13630 Protein ID WP_000584499.1
Coordinates 2626296..2626547 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAGV51_RS13600 2621456..2621992 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAGV51_RS13605 2622225..2623049 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAGV51_RS13610 2623266..2623448 - 183 WP_000230294.1 hypothetical protein -
SAGV51_RS13615 2623532..2623999 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAGV51_RS13620 2624185..2625735 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAGV51_RS16410 2625924..2625995 - 72 Protein_2595 hypothetical protein -
SAGV51_RS13625 2626030..2626296 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAGV51_RS13630 2626296..2626547 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAGV51_RS13635 2626712..2626813 - 102 WP_001791744.1 hypothetical protein -
SAGV51_RS13640 2626820..2627419 - 600 WP_000162813.1 DsbA family protein -
SAGV51_RS13645 2627438..2627800 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAGV51_RS13650 2628055..2629305 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
SAGV51_RS13655 2629402..2630133 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAGV51_RS13660 2630130..2630849 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T55504 WP_000113262.1 NZ_CP012015:c2626296-2626030 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T55504 NZ_CP012015:c2626296-2626030 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT55504 WP_000584499.1 NZ_CP012015:c2626547-2626296 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT55504 NZ_CP012015:c2626547-2626296 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References