Detailed information of TA system TA055487

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1679056..1679635
• Replicon: chromosome
• Accession: NZ_CP012015
• Organism: Staphylococcus aureus strain Gv51

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAGV51_RS08400
• Protein ID: WP_001025401.1
• Coordinates: 1679390..1679635 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1679056..1679421 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV51_RS08360	1675799..1676356	-	558	WP_000645042.1	DUF2815 family protein	-
SAGV51_RS08365	1676382..1677548	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SAGV51_RS08370	1677545..1677907	-	363	WP_000985984.1	hypothetical protein	-
SAGV51_RS08375	1677922..1678245	-	324	WP_000175001.1	hypothetical protein	-
SAGV51_RS08380	1678324..1678485	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAGV51_RS08385	1678498..1678761	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAGV51_RS08390	1678786..1679001	-	216	WP_001097552.1	hypothetical protein	-
SAGV51_RS08395	1679056..1679421	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAGV51_RS08400	1679390..1679635	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAGV51_RS08405	1679691..1679899	+	209	Protein_1627	hypothetical protein	-
SAGV51_RS08410	1679889..1680032	-	144	WP_000939498.1	hypothetical protein	-
SAGV51_RS08415	1680061..1680837	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SAGV51_RS08420	1680851..1681087	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SAGV51_RS08425	1681239..1681553	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SAGV51_RS08430	1681566..1682027	+	462	WP_000525004.1	hypothetical protein	-
SAGV51_RS08435	1682045..1682629	+	585	WP_000825948.1	hypothetical protein	-
SAGV51_RS08440	1682859..1683005	+	147	WP_001013104.1	hypothetical protein	-
SAGV51_RS08445	1683002..1683616	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1635836..1702577	66741

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T55487 WP_001025401.1 NZ_CP012015:c1679635-1679390 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T55487 NZ_CP012015:c1679635-1679390 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT55487 NZ_CP012015:1679056-1679421 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin