Detailed information of TA system TA055486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1181276..1181690
• Replicon: chromosome
• Accession: NZ_CP012015
• Organism: Staphylococcus aureus strain Gv51

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: SAGV51_RS05930
• Protein ID: WP_052998299.1
• Coordinates: 1181276..1181527 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SAGV51_RS16485
• Protein ID: WP_000028423.1
• Coordinates: 1181517..1181690 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAGV51_RS05870	1176636..1177406	+	771	WP_000190226.1	conserved phage C-terminal domain-containing protein	-
SAGV51_RS05875	1177416..1178189	+	774	WP_020444664.1	ATP-binding protein	-
SAGV51_RS16480	1178183..1178344	+	162	WP_000237153.1	hypothetical protein	-
SAGV51_RS05885	1178357..1178578	+	222	WP_001123688.1	DUF3269 family protein	-
SAGV51_RS05890	1178588..1178992	+	405	WP_000049780.1	DUF1064 domain-containing protein	-
SAGV51_RS05895	1178997..1179182	+	186	WP_001187243.1	DUF3113 family protein	-
SAGV51_RS05900	1179183..1179488	+	306	WP_000101252.1	hypothetical protein	-
SAGV51_RS05905	1179616..1179972	+	357	WP_000029376.1	hypothetical protein	-
SAGV51_RS05910	1179976..1180218	+	243	WP_001838823.1	phi PVL orf 51-like protein	-
SAGV51_RS05915	1180254..1180634	+	381	WP_020444718.1	hypothetical protein	-
SAGV51_RS05920	1180631..1180978	+	348	WP_000979209.1	hypothetical protein	-
SAGV51_RS05925	1180975..1181283	+	309	WP_001668981.1	hypothetical protein	-
SAGV51_RS05930	1181276..1181527	+	252	WP_052998299.1	DUF1024 family protein	Toxin
SAGV51_RS16485	1181517..1181690	+	174	WP_000028423.1	hypothetical protein	Antitoxin
SAGV51_RS16490	1181691..1181852	+	162	WP_000889680.1	hypothetical protein	-
SAGV51_RS05935	1181867..1182400	+	534	WP_031790047.1	dUTPase	-
SAGV51_RS05940	1182437..1182673	+	237	WP_020444716.1	DUF1381 domain-containing protein	-
SAGV51_RS05945	1182698..1182934	+	237	WP_020444715.1	hypothetical protein	-
SAGV51_RS05950	1182927..1183100	+	174	WP_015988676.1	transcriptional activator RinB	-
SAGV51_RS05955	1183101..1183502	+	402	WP_000286968.1	hypothetical protein	-
SAGV51_RS05960	1183853..1184347	+	495	WP_042857076.1	terminase	-
SAGV51_RS05965	1184340..1185563	+	1224	WP_001037586.1	PBSX family phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1165539..1208620	43081

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9418.28 Da
• Isoelectric Point: 3.8146

>T55486 WP_052998299.1 NZ_CP012015:1181276-1181527 [Staphylococcus aureus]
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKRAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T55486 NZ_CP012015:1181276-1181527 [Staphylococcus aureus]
ATGGATAACCGCGAACAAATCGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGTTAAA
AGAGATTGAGGACGTGTATAAGAGAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6482.32 Da
• Isoelectric Point: 4.2484

>AT55486 WP_000028423.1 NZ_CP012015:1181517-1181690 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSIISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT55486 NZ_CP012015:1181517-1181690 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAATTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA