Detailed information of TA system TA055473

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2187613..2187912
• Replicon: chromosome
• Accession: NZ_CP012013
• Organism: Staphylococcus aureus strain Be62

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: SABE62_RS16055
• Protein ID: WP_072482930.1
• Coordinates: 2187736..2187912 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2187613..2187668 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SABE62_RS11145	2184292..2184741	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
SABE62_RS16420	2184836..2185171	-	336	Protein_2125	SH3 domain-containing protein	-
SABE62_RS11155	2185821..2186312	-	492	WP_000919350.1	staphylokinase	-
SABE62_RS11160	2186503..2187258	-	756	WP_000861038.1	CHAP domain-containing protein	-
SABE62_RS11165	2187270..2187524	-	255	WP_000611512.1	phage holin	-
SABE62_RS11170	2187576..2187683	+	108	Protein_2129	hypothetical protein	-
-	2187605..2187744	+	140	NuclAT_0	-	-
-	2187605..2187744	+	140	NuclAT_0	-	-
-	2187605..2187744	+	140	NuclAT_0	-	-
-	2187605..2187744	+	140	NuclAT_0	-	-
-	2187613..2187668	+	56	-	-	Antitoxin
SABE62_RS16055	2187736..2187912	-	177	WP_072482930.1	putative holin-like toxin	Toxin
SABE62_RS11175	2188062..2188358	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SABE62_RS11180	2188416..2188703	-	288	WP_001040261.1	hypothetical protein	-
SABE62_RS11185	2188750..2188902	-	153	WP_001153681.1	hypothetical protein	-
SABE62_RS11190	2188892..2192677	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2181929..2238395	56466
	-	flank	IS/Tn	-	-	2182343..2183515	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T55473 WP_072482930.1 NZ_CP012013:c2187912-2187736 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T55473 NZ_CP012013:c2187912-2187736 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT55473 NZ_CP012013:2187613-2187668 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin