Detailed information of TA system TA055467

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1683552..1684131
• Replicon: chromosome
• Accession: NZ_CP012013
• Organism: Staphylococcus aureus strain Be62

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SABE62_RS08420
• Protein ID: WP_001025401.1
• Coordinates: 1683886..1684131 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1683552..1683917 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SABE62_RS08380	1680295..1680852	-	558	WP_000645042.1	DUF2815 family protein	-
SABE62_RS08385	1680878..1682044	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SABE62_RS08390	1682041..1682403	-	363	WP_000985984.1	hypothetical protein	-
SABE62_RS08395	1682418..1682741	-	324	WP_000175001.1	hypothetical protein	-
SABE62_RS08400	1682820..1682981	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SABE62_RS08405	1682994..1683257	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SABE62_RS08410	1683282..1683497	-	216	WP_001097552.1	hypothetical protein	-
SABE62_RS08415	1683552..1683917	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SABE62_RS08420	1683886..1684131	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SABE62_RS08425	1684187..1684395	+	209	Protein_1630	hypothetical protein	-
SABE62_RS08430	1684385..1684528	-	144	WP_000939498.1	hypothetical protein	-
SABE62_RS08435	1684557..1685333	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SABE62_RS08440	1685347..1685583	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SABE62_RS08445	1685735..1686048	+	314	Protein_1634	helix-turn-helix transcriptional regulator	-
SABE62_RS08450	1686061..1686522	+	462	WP_000525004.1	hypothetical protein	-
SABE62_RS08455	1686540..1687124	+	585	WP_000825948.1	hypothetical protein	-
SABE62_RS08460	1687354..1687500	+	147	WP_001013104.1	hypothetical protein	-
SABE62_RS08465	1687497..1688111	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1641673..1699973	58300

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T55467 WP_001025401.1 NZ_CP012013:c1684131-1683886 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T55467 NZ_CP012013:c1684131-1683886 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT55467 NZ_CP012013:1683552-1683917 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin