Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1179255..1179669 Replicon chromosome
Accession NZ_CP012013
Organism Staphylococcus aureus strain Be62

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SABE62_RS05920 Protein ID WP_052998299.1
Coordinates 1179255..1179506 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SABE62_RS16520 Protein ID WP_000028423.1
Coordinates 1179496..1179669 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SABE62_RS05860 1174787..1175557 + 771 WP_059290428.1 conserved phage C-terminal domain-containing protein -
SABE62_RS05865 1175567..1176338 + 772 Protein_1136 ATP-binding protein -
SABE62_RS16515 1176332..1176493 + 162 WP_000237153.1 hypothetical protein -
SABE62_RS05875 1176506..1176727 + 222 WP_041205435.1 DUF3269 family protein -
SABE62_RS05880 1176737..1177141 + 405 WP_000049780.1 DUF1064 domain-containing protein -
SABE62_RS05885 1177146..1177331 + 186 WP_001187239.1 DUF3113 family protein -
SABE62_RS05890 1177332..1177695 + 364 Protein_1141 hypothetical protein -
SABE62_RS05895 1177695..1177949 + 255 WP_031782732.1 DUF3310 domain-containing protein -
SABE62_RS05900 1177949..1178197 + 249 WP_072466103.1 hypothetical protein -
SABE62_RS05905 1178233..1178613 + 381 WP_020444718.1 hypothetical protein -
SABE62_RS05910 1178610..1178957 + 348 WP_000979209.1 hypothetical protein -
SABE62_RS05915 1178954..1179262 + 309 WP_001668981.1 hypothetical protein -
SABE62_RS05920 1179255..1179506 + 252 WP_052998299.1 DUF1024 family protein Toxin
SABE62_RS16520 1179496..1179669 + 174 WP_000028423.1 hypothetical protein Antitoxin
SABE62_RS16525 1179670..1179831 + 162 WP_000889680.1 hypothetical protein -
SABE62_RS05925 1179846..1180379 + 534 WP_031790047.1 dUTPase -
SABE62_RS05930 1180416..1180604 + 189 WP_000195793.1 DUF1381 domain-containing protein -
SABE62_RS05935 1180579..1180779 + 201 WP_001125015.1 hypothetical protein -
SABE62_RS05940 1180782..1180955 + 174 WP_001797333.1 transcriptional activator RinB -
SABE62_RS05945 1180956..1181102 + 147 WP_000990002.1 hypothetical protein -
SABE62_RS05950 1181117..1181536 + 420 WP_000058632.1 transcriptional regulator -
SABE62_RS05955 1181724..1182164 + 441 WP_001003271.1 terminase small subunit -
SABE62_RS05960 1182151..1183428 + 1278 WP_000169946.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1159708..1207614 47906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9418.28 Da        Isoelectric Point: 3.8146

>T55466 WP_052998299.1 NZ_CP012013:1179255-1179506 [Staphylococcus aureus]
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKRAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T55466 NZ_CP012013:1179255-1179506 [Staphylococcus aureus]
ATGGATAACCGCGAACAAATCGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGTTAAA
AGAGATTGAGGACGTGTATAAGAGAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6482.32 Da        Isoelectric Point: 4.2484

>AT55466 WP_000028423.1 NZ_CP012013:1179496-1179669 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSIISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT55466 NZ_CP012013:1179496-1179669 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAATTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References