Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2673472..2673995 Replicon chromosome
Accession NZ_CP012012
Organism Staphylococcus aureus strain HC1335

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SAHC1335_RS13865 Protein ID WP_000074048.1
Coordinates 2673472..2673738 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag SAHC1335_RS13870 Protein ID WP_000587616.1
Coordinates 2673738..2673995 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1335_RS13845 2668782..2669966 - 1185 WP_031890832.1 MFS transporter -
SAHC1335_RS13850 2670362..2671138 - 777 WP_020444793.1 iron export ABC transporter permease subunit FetB -
SAHC1335_RS13855 2671131..2671793 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
SAHC1335_RS13860 2672041..2673117 - 1077 WP_020444794.1 M42 family metallopeptidase -
SAHC1335_RS13865 2673472..2673738 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SAHC1335_RS13870 2673738..2673995 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAHC1335_RS13880 2674354..2674809 + 456 WP_000732082.1 DUF1307 domain-containing protein -
SAHC1335_RS13885 2674977..2676563 - 1587 WP_020444795.1 FMN-binding glutamate synthase family protein -
SAHC1335_RS13890 2676758..2677507 + 750 WP_000072442.1 hypothetical protein -
SAHC1335_RS13895 2677731..2678924 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T55463 WP_000074048.1 NZ_CP012012:c2673738-2673472 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T55463 NZ_CP012012:c2673738-2673472 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT55463 WP_000587616.1 NZ_CP012012:c2673995-2673738 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT55463 NZ_CP012012:c2673995-2673738 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References