Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2641974..2642158 Replicon chromosome
Accession NZ_CP012012
Organism Staphylococcus aureus strain HC1335

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag SAHC1335_RS13710 Protein ID WP_000482650.1
Coordinates 2642051..2642158 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2641974..2642034 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1335_RS13685 2637503..2637670 - 168 WP_001790576.1 hypothetical protein -
SAHC1335_RS13695 2637901..2639635 - 1735 Protein_2612 ABC transporter ATP-binding protein -
SAHC1335_RS13700 2639660..2641423 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2641974..2642034 + 61 - - Antitoxin
SAHC1335_RS13710 2642051..2642158 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
SAHC1335_RS13715 2642292..2642678 - 387 WP_000779358.1 flippase GtxA -
SAHC1335_RS13720 2642946..2644088 + 1143 WP_001176863.1 glycerate kinase -
SAHC1335_RS13725 2644148..2644807 + 660 WP_000831298.1 membrane protein -
SAHC1335_RS13730 2644994..2646199 + 1206 WP_191993076.1 multidrug effflux MFS transporter -
SAHC1335_RS13735 2646322..2646795 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T55461 WP_000482650.1 NZ_CP012012:c2642158-2642051 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T55461 NZ_CP012012:c2642158-2642051 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT55461 NZ_CP012012:2641974-2642034 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References