Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2345831..2346094 Replicon chromosome
Accession NZ_CP012012
Organism Staphylococcus aureus strain HC1335

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAHC1335_RS12100 Protein ID WP_001802298.1
Coordinates 2345990..2346094 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2345831..2345995 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1335_RS12080 2342014..2342679 - 666 WP_001024094.1 SDR family oxidoreductase -
SAHC1335_RS12085 2342831..2343151 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAHC1335_RS12090 2343153..2344133 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
SAHC1335_RS12095 2344399..2345490 + 1092 WP_000495671.1 lytic regulatory protein -
- 2345831..2345995 + 165 - - Antitoxin
SAHC1335_RS12100 2345990..2346094 - 105 WP_001802298.1 hypothetical protein Toxin
SAHC1335_RS16355 2346255..2346738 - 484 Protein_2315 recombinase family protein -
SAHC1335_RS12110 2346781..2347917 - 1137 WP_000115564.1 SAP domain-containing protein -
SAHC1335_RS12115 2348206..2348298 + 93 WP_001790138.1 hypothetical protein -
SAHC1335_RS12120 2349003..2349860 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
SAHC1335_RS12125 2349928..2350710 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T55458 WP_001802298.1 NZ_CP012012:c2346094-2345990 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T55458 NZ_CP012012:c2346094-2345990 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT55458 NZ_CP012012:2345831-2345995 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References