Detailed information of TA system TA055450

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2174810..2175109
• Replicon: chromosome
• Accession: NZ_CP012012
• Organism: Staphylococcus aureus strain HC1335

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: SAHC1335_RS15945
• Protein ID: WP_078156886.1
• Coordinates: 2174933..2175109 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2174810..2174865 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1335_RS11070	2171489..2171938	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
SAHC1335_RS16350	2172033..2172368	-	336	Protein_2113	SH3 domain-containing protein	-
SAHC1335_RS11080	2173018..2173509	-	492	WP_000919350.1	staphylokinase	-
SAHC1335_RS11085	2173700..2174455	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAHC1335_RS11090	2174467..2174721	-	255	WP_000611512.1	phage holin	-
SAHC1335_RS11095	2174773..2174880	+	108	Protein_2117	hypothetical protein	-
-	2174802..2174941	+	140	NuclAT_0	-	-
-	2174802..2174941	+	140	NuclAT_0	-	-
-	2174802..2174941	+	140	NuclAT_0	-	-
-	2174802..2174941	+	140	NuclAT_0	-	-
-	2174810..2174865	+	56	-	-	Antitoxin
SAHC1335_RS15945	2174933..2175109	-	177	WP_078156886.1	putative holin-like toxin	Toxin
SAHC1335_RS11100	2175259..2175555	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAHC1335_RS11105	2175613..2175900	-	288	WP_001040261.1	hypothetical protein	-
SAHC1335_RS11110	2175947..2176099	-	153	WP_001153681.1	hypothetical protein	-
SAHC1335_RS11115	2176089..2179874	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2169125..2225595	56470
	-	flank	IS/Tn	-	-	2169540..2170712	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6873.43 Da
• Isoelectric Point: 10.6777

>T55450 WP_078156886.1 NZ_CP012012:c2175109-2174933 [Staphylococcus aureus]
MDRWWLSEYKEVVSMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T55450 NZ_CP012012:c2175109-2174933 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGTCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT55450 NZ_CP012012:2174810-2174865 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin