Detailed information of TA system TA055447

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2011195..2011377
• Replicon: chromosome
• Accession: NZ_CP012012
• Organism: Staphylococcus aureus strain HC1335

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAHC1335_RS16320
• Protein ID: WP_001801861.1
• Coordinates: 2011195..2011290 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2011318..2011377 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1335_RS10055	2006855..2007481	+	627	WP_000669046.1	hypothetical protein	-
SAHC1335_RS10060	2007522..2007866	+	345	WP_000627551.1	DUF3969 family protein	-
SAHC1335_RS10065	2007964..2008515	+	552	WP_000414205.1	hypothetical protein	-
SAHC1335_RS10070	2008733..2009374	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
SAHC1335_RS10075	2009488..2009673	-	186	WP_000809857.1	hypothetical protein	-
SAHC1335_RS10080	2009675..2009851	-	177	WP_000375476.1	hypothetical protein	-
SAHC1335_RS10085	2009862..2010245	-	384	WP_000070811.1	hypothetical protein	-
SAHC1335_RS10095	2010849..2010992	-	144	WP_001549059.1	transposase	-
SAHC1335_RS16320	2011195..2011290	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2011318..2011377	-	60	-	-	Antitoxin
SAHC1335_RS10100	2011413..2011514	+	102	WP_001791893.1	hypothetical protein	-
SAHC1335_RS15860	2011492..2011668	-	177	Protein_1958	transposase	-
SAHC1335_RS10105	2011862..2012239	-	378	WP_001037045.1	DUF1433 domain-containing protein	-
SAHC1335_RS10110	2012760..2014085	-	1326	Protein_1960	ATP-binding protein	-
SAHC1335_RS10115	2014189..2015361	+	1173	WP_000195429.1	IS256-like element IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2014189..2015361	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T55447 WP_001801861.1 NZ_CP012012:2011195-2011290 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T55447 NZ_CP012012:2011195-2011290 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT55447 NZ_CP012012:c2011377-2011318 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin