Detailed information of TA system TA055443

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1673187..1673766
• Replicon: chromosome
• Accession: NZ_CP012012
• Organism: Staphylococcus aureus strain HC1335

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAHC1335_RS08355
• Protein ID: WP_001025401.1
• Coordinates: 1673521..1673766 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1673187..1673552 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1335_RS08315	1669930..1670487	-	558	WP_000645042.1	DUF2815 family protein	-
SAHC1335_RS08320	1670513..1671679	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SAHC1335_RS08325	1671676..1672038	-	363	WP_000985984.1	hypothetical protein	-
SAHC1335_RS08330	1672053..1672376	-	324	WP_000175001.1	hypothetical protein	-
SAHC1335_RS08335	1672455..1672616	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAHC1335_RS08340	1672629..1672892	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAHC1335_RS08345	1672917..1673132	-	216	WP_001097552.1	hypothetical protein	-
SAHC1335_RS08350	1673187..1673552	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAHC1335_RS08355	1673521..1673766	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAHC1335_RS08360	1673822..1674031	+	210	WP_000642492.1	hypothetical protein	-
SAHC1335_RS08365	1674021..1674164	-	144	WP_000939498.1	hypothetical protein	-
SAHC1335_RS08370	1674193..1674969	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SAHC1335_RS08375	1674983..1675219	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SAHC1335_RS08380	1675371..1675685	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SAHC1335_RS08385	1675698..1676159	+	462	WP_000525004.1	hypothetical protein	-
SAHC1335_RS08390	1676177..1676761	+	585	WP_000825948.1	hypothetical protein	-
SAHC1335_RS08395	1676991..1677137	+	147	WP_001013104.1	hypothetical protein	-
SAHC1335_RS08400	1677134..1677748	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1633099..1691835	58736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T55443 WP_001025401.1 NZ_CP012012:c1673766-1673521 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T55443 NZ_CP012012:c1673766-1673521 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT55443 NZ_CP012012:1673187-1673552 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin