Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1181049..1181463 Replicon chromosome
Accession NZ_CP012012
Organism Staphylococcus aureus strain HC1335

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SAHC1335_RS05940 Protein ID WP_052998299.1
Coordinates 1181049..1181300 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SAHC1335_RS16470 Protein ID WP_000028423.1
Coordinates 1181290..1181463 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1335_RS05880 1176551..1177331 + 781 Protein_1140 phage protein -
SAHC1335_RS05885 1177341..1178121 + 781 Protein_1141 ATP-binding protein -
SAHC1335_RS16465 1178115..1178288 + 174 WP_059287713.1 hypothetical protein -
SAHC1335_RS05895 1178291..1178512 + 222 WP_041205435.1 DUF3269 family protein -
SAHC1335_RS05900 1178522..1178924 + 403 Protein_1144 DUF1064 domain-containing protein -
SAHC1335_RS05905 1178934..1179120 + 187 Protein_1145 DUF3113 family protein -
SAHC1335_RS05910 1179121..1179487 + 367 Protein_1146 hypothetical protein -
SAHC1335_RS05915 1179487..1179741 + 255 WP_000022727.1 DUF3310 domain-containing protein -
SAHC1335_RS05920 1179741..1179989 + 249 WP_072466103.1 hypothetical protein -
SAHC1335_RS05925 1180002..1180406 + 405 WP_020444668.1 hypothetical protein -
SAHC1335_RS05930 1180403..1180750 + 348 WP_000979209.1 hypothetical protein -
SAHC1335_RS05935 1180747..1181056 + 310 Protein_1151 hypothetical protein -
SAHC1335_RS05940 1181049..1181300 + 252 WP_052998299.1 DUF1024 family protein Toxin
SAHC1335_RS16470 1181290..1181463 + 174 WP_000028423.1 hypothetical protein Antitoxin
SAHC1335_RS16475 1181464..1181625 + 162 WP_000889680.1 hypothetical protein -
SAHC1335_RS05945 1181640..1182173 + 534 WP_031790047.1 dUTPase -
SAHC1335_RS05950 1182210..1182398 + 189 WP_000195793.1 DUF1381 domain-containing protein -
SAHC1335_RS05955 1182373..1182573 + 201 WP_001125015.1 hypothetical protein -
SAHC1335_RS05960 1182576..1182749 + 174 WP_001797333.1 transcriptional activator RinB -
SAHC1335_RS05965 1182750..1182896 + 147 WP_000990002.1 hypothetical protein -
SAHC1335_RS05970 1182911..1183330 + 420 WP_000058632.1 transcriptional regulator -
SAHC1335_RS05975 1183518..1183958 + 441 WP_001003271.1 terminase small subunit -
SAHC1335_RS05980 1183945..1185222 + 1278 WP_000169946.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1166633..1209408 42775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9418.28 Da        Isoelectric Point: 3.8146

>T55442 WP_052998299.1 NZ_CP012012:1181049-1181300 [Staphylococcus aureus]
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKRAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T55442 NZ_CP012012:1181049-1181300 [Staphylococcus aureus]
ATGGATAACCGCGAACAAATCGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGTTAAA
AGAGATTGAGGACGTGTATAAGAGAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6482.32 Da        Isoelectric Point: 4.2484

>AT55442 WP_000028423.1 NZ_CP012012:1181290-1181463 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSIISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT55442 NZ_CP012012:1181290-1181463 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAATTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References