Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2415089..2415352 Replicon chromosome
Accession NZ_CP012011
Organism Staphylococcus aureus strain HC1340

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAHC1340_RS12565 Protein ID WP_001802298.1
Coordinates 2415248..2415352 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2415089..2415253 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHC1340_RS12545 2411272..2411937 - 666 WP_001024094.1 SDR family oxidoreductase -
SAHC1340_RS12550 2412089..2412409 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAHC1340_RS12555 2412411..2413391 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
SAHC1340_RS12560 2413657..2414748 + 1092 WP_000495671.1 lytic regulatory protein -
- 2415089..2415253 + 165 - - Antitoxin
SAHC1340_RS12565 2415248..2415352 - 105 WP_001802298.1 hypothetical protein Toxin
SAHC1340_RS16800 2415513..2415996 - 484 Protein_2400 recombinase family protein -
SAHC1340_RS12575 2416039..2417175 - 1137 WP_000115564.1 SAP domain-containing protein -
SAHC1340_RS12580 2417464..2417556 + 93 WP_001790138.1 hypothetical protein -
SAHC1340_RS12585 2418261..2419118 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
SAHC1340_RS12590 2419186..2419968 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T55434 WP_001802298.1 NZ_CP012011:c2415352-2415248 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T55434 NZ_CP012011:c2415352-2415248 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT55434 NZ_CP012011:2415089-2415253 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References