Detailed information of TA system TA055426

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2234130..2234429
• Replicon: chromosome
• Accession: NZ_CP012011
• Organism: Staphylococcus aureus strain HC1340

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAHC1340_RS16410
• Protein ID: WP_011447039.1
• Coordinates: 2234253..2234429 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2234130..2234185 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1340_RS11495	2229777..2230127	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
SAHC1340_RS11500	2230809..2231258	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
SAHC1340_RS16795	2231353..2231688	-	336	Protein_2194	SH3 domain-containing protein	-
SAHC1340_RS11510	2232338..2232829	-	492	WP_000919350.1	staphylokinase	-
SAHC1340_RS11515	2233020..2233775	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAHC1340_RS11520	2233787..2234041	-	255	WP_000611512.1	phage holin	-
SAHC1340_RS16405	2234093..2234200	+	108	WP_001791821.1	hypothetical protein	-
-	2234122..2234261	+	140	NuclAT_0	-	-
-	2234122..2234261	+	140	NuclAT_0	-	-
-	2234122..2234261	+	140	NuclAT_0	-	-
-	2234122..2234261	+	140	NuclAT_0	-	-
-	2234130..2234185	+	56	-	-	Antitoxin
SAHC1340_RS16410	2234253..2234429	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAHC1340_RS11525	2234579..2234875	-	297	WP_042857037.1	DUF2951 domain-containing protein	-
SAHC1340_RS11530	2234933..2235220	-	288	WP_001040261.1	hypothetical protein	-
SAHC1340_RS11535	2235267..2235419	-	153	WP_001153681.1	hypothetical protein	-
SAHC1340_RS11540	2235409..2239194	-	3786	WP_042857036.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb	2228065..2277501	49436
	-	flank	IS/Tn	-	-	2228065..2229669	1604

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T55426 WP_011447039.1 NZ_CP012011:c2234429-2234253 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T55426 NZ_CP012011:c2234429-2234253 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT55426 NZ_CP012011:2234130-2234185 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin