Detailed information of TA system TA055419

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1727732..1728311
• Replicon: chromosome
• Accession: NZ_CP012011
• Organism: Staphylococcus aureus strain HC1340

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAHC1340_RS08760
• Protein ID: WP_001025401.1
• Coordinates: 1728066..1728311 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1727732..1728097 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1340_RS08720	1724475..1725032	-	558	WP_000645042.1	DUF2815 family protein	-
SAHC1340_RS08725	1725058..1726224	-	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SAHC1340_RS08730	1726221..1726583	-	363	WP_000985984.1	hypothetical protein	-
SAHC1340_RS08735	1726598..1726921	-	324	WP_000175001.1	hypothetical protein	-
SAHC1340_RS08740	1727000..1727161	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAHC1340_RS08745	1727174..1727437	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAHC1340_RS08750	1727462..1727677	-	216	WP_001097552.1	hypothetical protein	-
SAHC1340_RS08755	1727732..1728097	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAHC1340_RS08760	1728066..1728311	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAHC1340_RS08765	1728367..1728576	+	210	WP_000642492.1	hypothetical protein	-
SAHC1340_RS08770	1728566..1728709	-	144	WP_000939498.1	hypothetical protein	-
SAHC1340_RS08775	1728738..1729514	-	777	WP_031886646.1	Rha family transcriptional regulator	-
SAHC1340_RS08780	1729528..1729773	-	246	WP_001573844.1	helix-turn-helix domain-containing protein	-
SAHC1340_RS08785	1729965..1730294	+	330	WP_001573842.1	helix-turn-helix domain-containing protein	-
SAHC1340_RS08790	1730307..1730768	+	462	WP_000525004.1	hypothetical protein	-
SAHC1340_RS08795	1730786..1731370	+	585	WP_000825948.1	hypothetical protein	-
SAHC1340_RS08800	1731600..1731746	+	147	WP_001013104.1	hypothetical protein	-
SAHC1340_RS08805	1731743..1732357	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1684583..1751319	66736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T55419 WP_001025401.1 NZ_CP012011:c1728311-1728066 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T55419 NZ_CP012011:c1728311-1728066 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT55419 NZ_CP012011:1727732-1728097 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin