Detailed information of TA system TA055415

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 413682..414020
• Replicon: chromosome
• Accession: NZ_CP012011
• Organism: Staphylococcus aureus strain HC1340

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAHC1340_RS15930
• Protein ID: WP_011447039.1
• Coordinates: 413682..413858 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	413846..414020 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAHC1340_RS15925	408913..412702	+	3790	Protein_393	hypothetical protein	-
SAHC1340_RS02000	412692..412844	+	153	WP_001153681.1	hypothetical protein	-
SAHC1340_RS02005	412891..413178	+	288	WP_001040261.1	hypothetical protein	-
SAHC1340_RS02010	413236..413532	+	297	WP_042857037.1	DUF2951 domain-containing protein	-
SAHC1340_RS15930	413682..413858	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	413846..414020	-	175	-	-	Antitoxin
SAHC1340_RS02020	414070..414324	+	255	WP_000611512.1	phage holin	-
SAHC1340_RS02025	414336..415091	+	756	WP_000861038.1	CHAP domain-containing protein	-
SAHC1340_RS02030	415989..416816	-	828	WP_000136022.1	alpha/beta hydrolase	-
SAHC1340_RS02035	416874..418088	-	1215	WP_000286469.1	NADH-dependent flavin oxidoreductase	-
SAHC1340_RS02040	418184..418282	+	99	WP_001803958.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	374436..415091	40655

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T55415 WP_011447039.1 NZ_CP012011:413682-413858 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T55415 NZ_CP012011:413682-413858 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT55415 NZ_CP012011:c414020-413846 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin