55394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1241959..1243222 Replicon chromosome
Accession NZ_CP011995
Organism Porphyromonas gingivalis strain A7436

Toxin (Protein)


Gene name HipT Uniprot ID Q7MW07
Locus tag PGA7_RS05210 Protein ID WP_010956143.1
Coordinates 1241959..1242897 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q7MW08
Locus tag PGA7_RS05215 Protein ID WP_005874041.1
Coordinates 1242887..1243222 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGA7_RS05200 1238033..1241515 - 3483 WP_005874047.1 DEAD/DEAH box helicase family protein -
PGA7_RS05205 1241569..1241889 - 321 WP_043876418.1 helix-turn-helix domain-containing protein -
PGA7_RS05210 1241959..1242897 - 939 WP_010956143.1 HipA domain-containing protein Toxin
PGA7_RS05215 1242887..1243222 - 336 WP_005874041.1 HipA N-terminal domain-containing protein Antitoxin
PGA7_RS05220 1243219..1243443 - 225 WP_005874043.1 helix-turn-helix transcriptional regulator -
PGA7_RS05225 1243667..1244572 - 906 WP_005874039.1 hypothetical protein -
PGA7_RS05230 1245074..1245856 - 783 WP_004584112.1 DUF4393 domain-containing protein -
PGA7_RS05235 1245893..1246378 - 486 WP_005874045.1 HU family DNA-binding protein -
PGA7_RS05240 1246808..1247889 - 1082 Protein_1024 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-280)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36101.60 Da        Isoelectric Point: 6.1022

>T55394 WP_010956143.1 NZ_CP011995:c1242897-1241959 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI

Download         Length: 939 bp

>T55394 NZ_CP011995:c1242897-1241959 [Porphyromonas gingivalis]
ATGACGAATAGATGCCTATACTGCTACGAACCTTTGGTTGATGGAGAGATGGATTACCATGCCAAGTGTTGTCGCAAATT
GTTTGGGACGCCCCAAGCTCCTATATTGCCTTATACAAGTAGCGAAGTACGAGCGTTGGCTGACGAGGTCGTTCGTTCGC
AAACCACAGTGACAGGAGTACAACCCAAGCTATCTCTCGACTTTGACCAAATGAGCAATTCGCCCAAGCGATTTACCATC
GTGGGCTTGTGGGGACGGTTTATTCTTAAACCTCAAACAGAGCGTTATTCGCATCTCCCTGAATTGGAGGATGTGTCAAT
GCACCTTGCAGAGATTGCCAAGATAGAAACAGTTCCTCATGGACTGATGCGATTTAGCGATGGCGAACTATGCTATATCA
CTCGTCGCATAGACCGAACAGGGCAAGGGGAAAAGCTCCCAATGGAAGATATGTGCCAGCTCTCAGAGCGTCTGACCGAA
TATAAATACAAAGGCTCACACGAGCAGGTAGCCAAGCTGATCTCCAAGTATAGCTCTGTGCCAAAACTTGATCTTGTCAA
GTACTGGGAGCAGGTACTCTTTTCGTGGCTGATAGGTAATGCCGATATGCACCTCAAGAATTACTCGCTCTATGCTCCAG
AGGGAAATGAATATCAACTCACTCCAGCTTACGACCTGCTGTCTACGGCACTTGTTATTCCTGAGGATACAGAAGAACTT
GCATTGACCCTCTGTGGCAAAAAGCGCAAACTCACTCGCCAACACTTCCTCGAAGCGATGACAGCCTCAGGACTAGATGA
GAAAGTGTGTGACAATATTTTCGCTCGCTTCCAACACATCCTCCCCGAATGGGAAGCCTGCATCCGTCAGAGCTTCTTAC
CGACAGAGATGCAGAGACAATACATCGAATTTATTCTCCTCAAATTCTCTCAAATCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12679.49 Da        Isoelectric Point: 4.1551

>AT55394 WP_005874041.1 NZ_CP011995:c1243222-1242887 [Porphyromonas gingivalis]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE

Download         Length: 336 bp

>AT55394 NZ_CP011995:c1243222-1242887 [Porphyromonas gingivalis]
ATGAAACAGGCAATTGTTTATTGGAAGACACTCAAAGCAGGCATTCTCACAGAAAGTGATGAGGGCTATTCCTTTGCTTA
CGACAAGGACTATCTGACTATGCCCGAAGCTCAAGGCATAAGCCTAACAATGCCTTTGCGAGAAGAACCTTTCCAAAGCA
ATATGCTTCATCCATTTTTTGACGGACTTATCCCTGAGGGATGGCTGTTAGATATTGCTCAGAAGAATTGGAAGATAGAC
TCAAGGGATCGAATGGCTTTACTACTGGCTTGTTGCCGAGACTGCATTGGAGCGGTAAGTATCGAACCCCTAAATACGAC
TGAAGATGACGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7MW07

Antitoxin

Source ID Structure
AlphaFold DB Q7MW08

References