Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1978931..1979549 Replicon chromosome
Accession NZ_CP011971
Organism Steroidobacter denitrificans strain DSM 18526

Toxin (Protein)


Gene name higB Uniprot ID A0A127FA04
Locus tag ACG33_RS09100 Protein ID WP_066920550.1
Coordinates 1979253..1979549 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A127F9Z7
Locus tag ACG33_RS09095 Protein ID WP_066920548.1
Coordinates 1978931..1979239 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACG33_RS09065 1974162..1975619 - 1458 WP_083536638.1 PhoH family protein -
ACG33_RS09070 1975624..1976097 - 474 WP_066920542.1 peroxiredoxin -
ACG33_RS09075 1976153..1976704 - 552 WP_210398983.1 amino acid-binding protein -
ACG33_RS09080 1976995..1977873 + 879 WP_066920546.1 4-hydroxy-tetrahydrodipicolinate synthase -
ACG33_RS16530 1978119..1978514 - 396 WP_210398984.1 hypothetical protein -
ACG33_RS16535 1978502..1978912 - 411 WP_210398985.1 recombinase family protein -
ACG33_RS09095 1978931..1979239 - 309 WP_066920548.1 HigA family addiction module antidote protein Antitoxin
ACG33_RS09100 1979253..1979549 - 297 WP_066920550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACG33_RS16120 1979613..1979783 - 171 WP_157071733.1 hypothetical protein -
ACG33_RS09105 1980173..1981738 + 1566 WP_066920552.1 FadD3 family acyl-CoA ligase -
ACG33_RS09110 1981731..1982486 - 756 WP_066920554.1 glucose 1-dehydrogenase -
ACG33_RS09115 1982594..1984063 - 1470 WP_066920556.1 catalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11631.04 Da        Isoelectric Point: 6.7267

>T55295 WP_066920550.1 NZ_CP011971:c1979549-1979253 [Steroidobacter denitrificans]
VIVGFRDGWLRAFFVDDVRSRNIPSDLEARLFRKLQMIDDAVTDQDLRVPPSNHFERLRGNLAGFHSIRVNQQWRLIFRW
DGERGEADGIYLDDHSYR

Download         Length: 297 bp

>T55295 NZ_CP011971:c1979549-1979253 [Steroidobacter denitrificans]
GTGATCGTAGGCTTTCGGGACGGCTGGCTTCGGGCTTTCTTTGTGGATGATGTTCGTTCCCGCAACATCCCATCCGATCT
TGAAGCCCGCTTGTTCCGCAAGCTCCAGATGATTGACGACGCCGTGACCGATCAGGACTTGCGCGTACCGCCCAGCAATC
ACTTCGAGAGGCTGCGCGGCAATCTCGCAGGTTTCCATTCGATCCGCGTCAACCAGCAATGGCGGTTGATCTTCCGCTGG
GATGGTGAACGCGGCGAGGCAGACGGGATTTATCTGGACGATCACAGCTACCGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11590.37 Da        Isoelectric Point: 11.2832

>AT55295 WP_066920548.1 NZ_CP011971:c1979239-1978931 [Steroidobacter denitrificans]
MLTTKRKPATVGEILTEEFMRPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGNSPDFWLNVQRRSDLW
EVMNTPRERERVERARPLQNAA

Download         Length: 309 bp

>AT55295 NZ_CP011971:c1979239-1978931 [Steroidobacter denitrificans]
ATGCTGACCACCAAGCGTAAGCCGGCGACTGTCGGCGAGATACTGACCGAAGAATTCATGCGGCCGATGGGGCTGACCCA
GGGCGCGCTCGCCGAGGCGATGGGCGTCCAGCGCAAGCACGTCAACGAGCTATGCGGCAACCGCAGGAACGTGACGGCGG
CGACGGCGCTGATCCTCGCCCGCGTGTTCGGCAACAGCCCGGACTTCTGGCTCAACGTGCAGCGGCGCAGCGATCTTTGG
GAGGTGATGAACACGCCCAGGGAGCGCGAGCGGGTTGAGCGCGCGCGCCCCTTGCAGAACGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127FA04

Antitoxin

Source ID Structure
AlphaFold DB A0A127F9Z7

References