Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3014347..3015040 Replicon chromosome
Accession NZ_CP011938
Organism Escherichia coli strain C43(DE3)

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag TZ57_RS14925 Protein ID WP_000415584.1
Coordinates 3014744..3015040 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag TZ57_RS14920 Protein ID WP_000650107.1
Coordinates 3014347..3014742 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TZ57_RS14910 3010211..3012469 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
TZ57_RS14915 3012607..3014214 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
TZ57_RS14920 3014347..3014742 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
TZ57_RS14925 3014744..3015040 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
TZ57_RS14930 3015245..3015727 - 483 WP_000183505.1 transcriptional regulator -
TZ57_RS14935 3015780..3016172 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
TZ57_RS14940 3016324..3016983 + 660 WP_001221493.1 two-component system response regulator QseB -
TZ57_RS14945 3016980..3018329 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
TZ57_RS14950 3018375..3018707 - 333 WP_000917684.1 DUF2645 family protein -
TZ57_RS14955 3019026..3019607 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
TZ57_RS14960 3019638..3019952 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T55244 WP_000415584.1 NZ_CP011938:c3015040-3014744 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T55244 NZ_CP011938:c3015040-3014744 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT55244 WP_000650107.1 NZ_CP011938:c3014742-3014347 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT55244 NZ_CP011938:c3014742-3014347 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References