Detailed information of TA system TA055213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 5272298..5273078
• Replicon: chromosome
• Accession: NZ_CP011930
• Organism: Herbaspirillum seropedicae strain Z67

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: D8IX29
• Locus tag: ACP92_RS22950
• Protein ID: WP_013236519.1
• Coordinates: 5272782..5273078 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: ACP92_RS22945
• Protein ID: WP_013236518.1
• Coordinates: 5272298..5272780 (-)
• Length: 161 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACP92_RS22925	5267463..5269025	-	1563	WP_041311350.1	MCP four helix bundle domain-containing protein	-
ACP92_RS22930	5269181..5270017	-	837	WP_013236515.1	amidohydrolase family protein	-
ACP92_RS22935	5270014..5271255	-	1242	WP_013236516.1	MFS transporter	-
ACP92_RS22940	5271556..5272290	+	735	WP_013236517.1	GntR family transcriptional regulator	-
ACP92_RS22945	5272298..5272780	-	483	WP_013236518.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ACP92_RS22950	5272782..5273078	-	297	WP_013236519.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ACP92_RS22955	5273515..5274192	+	678	WP_013236520.1	glutathione transferase	-
ACP92_RS22960	5274298..5275554	-	1257	WP_013236521.1	MFS transporter	-
ACP92_RS22965	5276016..5276738	+	723	WP_013236522.1	FadR family transcriptional regulator	-
ACP92_RS22970	5276822..5277625	-	804	WP_013236523.1	transporter substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10911.76 Da
• Isoelectric Point: 9.4837

>T55213 WP_013236519.1 NZ_CP011930:c5273078-5272782 [Herbaspirillum seropedicae]
MEKHTPHYKLAVVKSLLRQGQVRKTATALLGAAALGIDEMEMVAVVASLSSADFCKSMTTRADHRIWQDVYRPATRYGVL
YVKLTVLDDVLIVSFKES

Nucleotide

• Length: 297 bp

>T55213 NZ_CP011930:c5273078-5272782 [Herbaspirillum seropedicae]
ATGGAAAAACATACCCCACATTACAAGCTTGCAGTCGTGAAGTCCCTGCTCAGGCAGGGGCAGGTCCGCAAAACGGCGAC
CGCTCTTCTCGGTGCGGCGGCACTGGGCATCGATGAAATGGAAATGGTGGCCGTCGTCGCATCGTTGAGCAGCGCAGATT
TCTGCAAGAGCATGACCACCCGTGCTGATCACCGTATCTGGCAAGACGTCTATCGGCCTGCCACCCGCTACGGTGTCCTC
TACGTCAAGTTGACCGTGCTTGATGATGTGCTGATCGTATCCTTCAAGGAGAGCTGA

Antitoxin

Protein

• Length: 161 a.a.
• Molecular weight: 17455.06 Da
• Isoelectric Point: 8.3546

>AT55213 WP_013236518.1 NZ_CP011930:c5272780-5272298 [Herbaspirillum seropedicae]
MKCPHCGGAHLIRDTRDLPYAYKGETTVIATVTGDYCPRCGECLPTIEEEARISAEALAFNKEINAGMIDPAEIISTREA
LQLGQREASLLFGGGINAFNRYEAGKIQPPRALVLLLRLLRKHPELLSELRADAGMSARGQAVHSVQEAGAGRLRTRSRK

Nucleotide

• Length: 483 bp

>AT55213 NZ_CP011930:c5272780-5272298 [Herbaspirillum seropedicae]
ATGAAATGTCCCCATTGCGGAGGCGCGCACCTGATCCGCGACACGCGCGATCTGCCCTATGCCTACAAGGGCGAAACCAC
GGTCATTGCGACGGTCACCGGCGACTATTGCCCGCGCTGCGGCGAGTGTCTGCCGACCATCGAAGAAGAAGCCAGGATCT
CGGCCGAGGCGCTGGCCTTCAATAAGGAAATCAACGCCGGGATGATCGATCCCGCCGAAATCATCTCTACCCGCGAGGCC
CTGCAACTGGGCCAGCGCGAGGCCAGCCTGCTGTTCGGCGGAGGGATCAATGCCTTCAACCGCTATGAGGCCGGCAAGAT
CCAGCCGCCGCGTGCGCTGGTGCTGTTGTTGCGCCTGTTGCGCAAGCACCCGGAGTTGCTCAGTGAACTGCGCGCCGACG
CCGGCATGAGCGCGCGTGGCCAGGCCGTCCATTCGGTCCAGGAAGCCGGCGCCGGCCGCTTGCGGACCCGCTCGCGCAAG
TGA

Structures

Toxin

• AlphaFold DB: D8IX29