Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4880664..4881237 Replicon chromosome
Accession NZ_CP011930
Organism Herbaspirillum seropedicae strain Z67

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ACP92_RS21285 Protein ID WP_041312325.1
Coordinates 4880959..4881237 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ACP92_RS21280 Protein ID WP_013236194.1
Coordinates 4880664..4880939 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACP92_RS21260 4875770..4877326 + 1557 WP_013236190.1 ABC transporter ATP-binding protein -
ACP92_RS21265 4877319..4878413 + 1095 WP_013236191.1 ABC transporter permease -
ACP92_RS21270 4878430..4879350 + 921 WP_013236192.1 ABC transporter permease -
ACP92_RS21275 4879423..4880562 + 1140 WP_013236193.1 BMP family ABC transporter substrate-binding protein -
ACP92_RS21280 4880664..4880939 - 276 WP_013236194.1 HigA family addiction module antidote protein Antitoxin
ACP92_RS21285 4880959..4881237 - 279 WP_041312325.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACP92_RS21290 4881475..4882269 + 795 WP_048348632.1 septum site-determining protein MinC -
ACP92_RS21295 4882352..4883167 + 816 WP_013236197.1 septum site-determining protein MinD -
ACP92_RS21300 4883169..4883438 + 270 WP_006465131.1 cell division topological specificity factor MinE -
ACP92_RS21305 4883566..4884267 + 702 WP_013236198.1 response regulator transcription factor -
ACP92_RS21310 4884471..4885763 + 1293 WP_013236199.1 glutamyl-tRNA reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10328.88 Da        Isoelectric Point: 10.0459

>T55212 WP_041312325.1 NZ_CP011930:c4881237-4880959 [Herbaspirillum seropedicae]
MIKNFRHKGLQRFFETGSKAGIQAAHAGKLRLQLAALDQATQPEDLSAPAWALHPLKGELKGLWAITVNGNWRLIFAFEG
KDAVLVDYRDYH

Download         Length: 279 bp

>T55212 NZ_CP011930:c4881237-4880959 [Herbaspirillum seropedicae]
ATGATCAAGAATTTCCGACACAAAGGGCTGCAACGTTTCTTTGAGACGGGCAGCAAGGCTGGCATTCAGGCTGCTCATGC
GGGCAAGCTCAGGCTGCAGCTGGCCGCGCTGGACCAAGCCACCCAACCGGAAGATCTTTCTGCGCCCGCATGGGCGCTGC
ATCCACTAAAAGGTGAGCTCAAGGGGCTATGGGCGATCACCGTCAACGGCAATTGGCGGCTGATATTCGCTTTCGAGGGG
AAGGACGCGGTACTGGTGGATTACCGCGACTATCACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10008.55 Da        Isoelectric Point: 7.2013

>AT55212 WP_013236194.1 NZ_CP011930:c4880939-4880664 [Herbaspirillum seropedicae]
VNRMFNPPHPGEVLREYLGEMTVTEAAMRLGVSRVTLQRIVNGAAGISPDMAYRLAAAFGTSPELWAGMQLQYDLHAASK
LERPPIERITA

Download         Length: 276 bp

>AT55212 NZ_CP011930:c4880939-4880664 [Herbaspirillum seropedicae]
GTGAATCGCATGTTCAACCCACCTCACCCTGGCGAGGTGTTGAGGGAATACCTGGGTGAAATGACCGTGACCGAAGCCGC
CATGCGGCTTGGCGTCAGTCGCGTCACCCTGCAACGCATCGTCAACGGCGCAGCTGGCATCTCGCCGGATATGGCCTATC
GCCTGGCGGCTGCCTTTGGCACCAGTCCCGAACTGTGGGCCGGGATGCAGCTGCAATACGATCTGCATGCCGCCAGCAAG
CTGGAGCGCCCACCCATCGAGCGCATCACTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References