Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4913863..4914121 Replicon chromosome
Accession NZ_CP011915
Organism Escherichia coli strain PSUO2

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag ACJ74_RS25095 Protein ID WP_000809168.1
Coordinates 4913969..4914121 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4913863..4913920 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACJ74_RS25075 4909692..4910951 - 1260 WP_000494929.1 hypothetical protein -
ACJ74_RS25080 4911080..4912573 - 1494 WP_001350365.1 sulfatase-like hydrolase/transferase -
ACJ74_RS25085 4912593..4913354 - 762 WP_001274832.1 hypothetical protein -
- 4913863..4913920 - 58 - - Antitoxin
ACJ74_RS25095 4913969..4914121 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
ACJ74_RS25100 4914226..4915356 - 1131 WP_001118464.1 molecular chaperone DnaJ -
ACJ74_RS25105 4915445..4917361 - 1917 WP_000516135.1 molecular chaperone DnaK -
ACJ74_RS25110 4917733..4918137 + 405 WP_000843692.1 DUF2541 family protein -
ACJ74_RS25115 4918163..4918876 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T55187 WP_000809168.1 NZ_CP011915:4913969-4914121 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T55187 NZ_CP011915:4913969-4914121 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT55187 NZ_CP011915:c4913920-4913863 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References