55182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3374582..3375135 Replicon chromosome
Accession NZ_CP011915
Organism Escherichia coli strain PSUO2

Toxin (Protein)


Gene name higB Uniprot ID A0A0G9FUJ7
Locus tag ACJ74_RS17045 Protein ID WP_000605680.1
Coordinates 3374582..3374851 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag ACJ74_RS17050 Protein ID WP_000781370.1
Coordinates 3374851..3375135 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACJ74_RS17015 3370168..3370599 - 432 WP_000152305.1 peroxiredoxin OsmC -
ACJ74_RS17025 3370944..3371159 + 216 WP_000495766.1 biofilm-dependent modulation protein -
ACJ74_RS17030 3371261..3371398 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
ACJ74_RS17035 3371555..3373252 + 1698 WP_000433464.1 malate dehydrogenase -
ACJ74_RS17040 3373386..3374396 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
ACJ74_RS17045 3374582..3374851 + 270 WP_000605680.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACJ74_RS17050 3374851..3375135 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
ACJ74_RS17055 3375364..3376017 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
ACJ74_RS17060 3376010..3376894 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
ACJ74_RS17065 3376907..3379954 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-89)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10181.73 Da        Isoelectric Point: 6.8582

>T55182 WP_000605680.1 NZ_CP011915:3374582-3374851 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVNGDA
YILDYEDYH

Download         Length: 270 bp

>T55182 NZ_CP011915:3374582-3374851 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACACGATT
ACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTACATCCGTTAA
GCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAATGGCGATGCA
TACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT55182 WP_000781370.1 NZ_CP011915:3374851-3375135 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT55182 NZ_CP011915:3374851-3375135 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9FUJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References