55160

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3036387..3036991 Replicon chromosome
Accession NZ_CP011883
Organism Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag B586_RS21020 Protein ID WP_054879618.1
Coordinates 3036701..3036991 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B586_RS21015 Protein ID WP_054879619.1
Coordinates 3036387..3036686 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B586_RS14200 3031850..3033211 - 1362 WP_211141639.1 diaminopimelate decarboxylase -
B586_RS14205 3033265..3034917 - 1653 WP_047315857.1 arginine--tRNA ligase -
B586_RS14215 3035426..3035782 + 357 WP_156406785.1 hypothetical protein -
B586_RS21015 3036387..3036686 - 300 WP_054879619.1 HigA family addiction module antidote protein Antitoxin
B586_RS21020 3036701..3036991 - 291 WP_054879618.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B586_RS21645 3037459..3038713 + 1255 Protein_2857 PE family protein -
B586_RS21650 3038920..3039336 + 417 WP_054879617.1 hypothetical protein -
B586_RS14245 3039603..3040073 - 471 WP_054880898.1 hypothetical protein -
B586_RS14250 3040197..3040733 - 537 WP_054880897.1 pyridoxamine 5'-phosphate oxidase family protein -
B586_RS14255 3040764..3041249 - 486 WP_211141641.1 NUDIX domain-containing protein -
B586_RS14260 3041431..3041820 + 390 WP_047314893.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-64)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10967.42 Da        Isoelectric Point: 9.1571

>T55160 WP_054879618.1 NZ_CP011883:c3036991-3036701 [Mycobacterium haemophilum DSM 44634]
VIRSFSDSDTQKIWELRCPKGISKDLAKAVRRKMQILDAAENINDLRVPPGNRLEKLTAKGGREGQHSIRINDQYRICFK
WSNGGADNVELVDYHD

Download         Length: 291 bp

>T55160 NZ_CP011883:c3036991-3036701 [Mycobacterium haemophilum DSM 44634]
GTGATCCGGTCGTTCAGCGACAGCGACACCCAGAAGATCTGGGAGCTGCGCTGCCCGAAAGGGATCAGCAAGGATCTGGC
GAAAGCGGTTCGCCGGAAGATGCAGATCCTCGACGCCGCAGAGAACATCAACGATCTACGGGTTCCTCCAGGGAACCGCT
TGGAAAAGCTGACGGCTAAGGGCGGCCGTGAAGGGCAACACAGCATCCGCATCAACGACCAGTACCGAATCTGCTTCAAG
TGGAGCAACGGCGGCGCGGACAACGTTGAACTGGTTGACTACCACGACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10991.77 Da        Isoelectric Point: 6.4608

>AT55160 WP_054879619.1 NZ_CP011883:c3036686-3036387 [Mycobacterium haemophilum DSM 44634]
MADFAPTHPGEILAEEFLVPMRITPYRLAKEIGVPQTRLSEIIAGRRAITADTGLRLSRALGLSDMFWINLQARYDADMV
RIDKSAELEHIRPLAACAG

Download         Length: 300 bp

>AT55160 NZ_CP011883:c3036686-3036387 [Mycobacterium haemophilum DSM 44634]
ATGGCCGATTTCGCACCCACCCACCCCGGCGAGATCCTCGCCGAGGAGTTCCTGGTACCCATGAGGATCACCCCCTACCG
TCTCGCGAAGGAGATCGGCGTACCGCAGACCCGCCTGAGTGAGATCATCGCCGGCCGGCGTGCCATCACGGCTGACACTG
GGCTGCGGCTATCGCGGGCACTGGGCCTTAGTGACATGTTCTGGATCAACCTACAGGCGCGCTACGACGCCGACATGGTC
CGCATCGACAAGAGCGCCGAGCTCGAGCACATTCGTCCACTAGCTGCGTGCGCTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References