Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1203829..1204466 Replicon chromosome
Accession NZ_CP011883
Organism Mycobacterium haemophilum DSM 44634 strain ATCC 29548

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag B586_RS05770 Protein ID WP_054880460.1
Coordinates 1204155..1204466 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B586_RS05765 Protein ID WP_054880461.1
Coordinates 1203829..1204158 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B586_RS05745 1200140..1200790 - 651 WP_054880463.1 response regulator transcription factor -
B586_RS05750 1200821..1201627 - 807 WP_054881045.1 universal stress protein -
B586_RS05755 1201985..1202269 + 285 Protein_1163 slipin family protein -
B586_RS05760 1202395..1203378 + 984 WP_054880462.1 NAD(P)H nitroreductase -
B586_RS20765 1203453..1203620 + 168 WP_156406720.1 hypothetical protein -
B586_RS05765 1203829..1204158 - 330 WP_054880461.1 XRE family transcriptional regulator Antitoxin
B586_RS05770 1204155..1204466 - 312 WP_054880460.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B586_RS05775 1204537..1207899 - 3363 WP_054880459.1 AAA family ATPase -
B586_RS05780 1207892..1208608 - 717 WP_054880458.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-94)

Antitoxin

HigA2-like, helix-turn-helix domain

(37-97)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11450.04 Da        Isoelectric Point: 5.1651

>T55156 WP_054880460.1 NZ_CP011883:c1204466-1204155 [Mycobacterium haemophilum DSM 44634]
IGVGVLRSNLLEEVAGAIDLLELEGPTLGRPTVDKVDGSKYHSMKELRPAGTSIRILFIFDPRRQAILLLGGDQAGNWKS
WYDKNIPVAERRYENWLATEGGE

Download         Length: 312 bp

>T55156 NZ_CP011883:c1204466-1204155 [Mycobacterium haemophilum DSM 44634]
ATTGGTGTCGGCGTCCTGAGAAGTAATCTGCTCGAGGAGGTCGCTGGGGCCATCGACTTGCTCGAGCTGGAAGGGCCAAC
GCTGGGCCGGCCGACGGTAGACAAGGTCGACGGATCGAAATACCACAGCATGAAGGAGCTGCGGCCCGCGGGTACCAGCA
TCCGGATCCTGTTTATCTTCGATCCGCGGCGGCAGGCGATTCTGTTGCTCGGCGGCGACCAGGCGGGCAATTGGAAAAGT
TGGTACGACAAGAACATTCCGGTGGCAGAGCGGCGCTACGAGAACTGGCTCGCTACCGAGGGAGGTGAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11731.34 Da        Isoelectric Point: 10.0735

>AT55156 WP_054880461.1 NZ_CP011883:c1204158-1203829 [Mycobacterium haemophilum DSM 44634]
MIMARNWREIRADAIARGRLAPARVDAARKEMHDAVQAQRLADIRKAHGHARQADVAVAMGVSQARVSKLESGDLSHTEL
GTLQSYVAALGGNLRIVADFGESSVELTA

Download         Length: 330 bp

>AT55156 NZ_CP011883:c1204158-1203829 [Mycobacterium haemophilum DSM 44634]
ATGATCATGGCACGCAATTGGCGTGAGATACGCGCCGATGCCATCGCGCGCGGGCGCTTGGCCCCGGCCCGCGTCGATGC
CGCGCGCAAGGAAATGCACGATGCCGTCCAAGCGCAGCGTCTTGCCGATATCCGCAAGGCGCATGGCCACGCTCGTCAAG
CCGACGTCGCCGTCGCGATGGGAGTCTCCCAGGCACGAGTGTCCAAACTCGAAAGCGGCGATTTATCACATACGGAACTC
GGGACGTTGCAGTCGTATGTCGCTGCACTAGGCGGGAACCTCCGGATCGTCGCCGACTTCGGCGAGAGCAGTGTGGAGCT
GACTGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References