Detailed information of TA system TA055071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 86266..86966
• Replicon: plasmid pPF72-2
• Accession: NZ_CP011809
• Organism: Pandoraea faecigallinarum strain DSM 23572

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3X411
• Locus tag: AB870_RS25325
• Protein ID: WP_047909461.1
• Coordinates: 86266..86562 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A0H3X0L6
• Locus tag: AB870_RS25330
• Protein ID: WP_047909513.1
• Coordinates: 86565..86966 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB870_RS25300	81770..83449	+	1680	WP_047909456.1	tyrosine-type recombinase/integrase	-
AB870_RS25305	83446..83868	+	423	Protein_86	DUF4158 domain-containing protein	-
AB870_RS25310	83912..84655	+	744	WP_047909458.1	IS6 family transposase	-
AB870_RS26195	84717..84845	-	129	Protein_88	single-stranded DNA-binding protein	-
AB870_RS25315	84995..85636	-	642	WP_047909459.1	hypothetical protein	-
AB870_RS25320	85633..85974	-	342	WP_047909460.1	hypothetical protein	-
AB870_RS25325	86266..86562	+	297	WP_047909461.1	type II toxin-antitoxin system MqsR family toxin	Toxin
AB870_RS25330	86565..86966	+	402	WP_047909513.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
AB870_RS26710	87187..87429	-	243	Protein_93	IS6 family transposase	-
AB870_RS25340	87480..88217	+	738	WP_047909443.1	IS6 family transposase	-
AB870_RS25345	88352..90481	-	2130	WP_047909462.1	TonB-dependent copper receptor	-
AB870_RS25350	90567..90947	-	381	WP_047909463.1	DUF2946 domain-containing protein	-
AB870_RS26200	91553..91882	+	330	WP_084664399.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..104368	104368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10875.66 Da
• Isoelectric Point: 8.0736

>T55071 WP_047909461.1 NZ_CP011809:86266-86562 [Pandoraea faecigallinarum]
MEKRTPHCKLIVVKALIEAGKVRTTHAARTGATELGLAFSDMLAVVKALTPTDFYKSMTTHADHTVWQDVYRPSTQAGDV
YLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T55071 NZ_CP011809:86266-86562 [Pandoraea faecigallinarum]
ATGGAGAAACGAACCCCGCATTGCAAGTTGATAGTCGTCAAAGCCTTGATCGAGGCAGGCAAAGTGCGCACGACGCATGC
GGCGCGTACCGGCGCCACCGAGTTGGGGCTTGCCTTCTCCGACATGCTGGCGGTGGTGAAGGCACTCACGCCAACGGACT
TCTACAAGAGCATGACCACCCATGCCGATCACACGGTATGGCAGGACGTGTACCGCCCCAGCACGCAGGCGGGCGACGTG
TACCTGAAGCTGACGGTCATCGATGACGTGCTGATCGTGTCCTTCAAGGAGCTATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14754.07 Da
• Isoelectric Point: 6.2283

>AT55071 WP_047909513.1 NZ_CP011809:86565-86966 [Pandoraea faecigallinarum]
MKCPVCGAAELIHDTRDLPYTYKGETTMIPAVTADFCPACDESITDMAETERVMGEMQAFHRQVNAAIVDPAFIVKVRKK
LDLGQREAAEIFGGGINAFSRYENGKTKPPLALVKLFKLLDRHPDLLNEVRTA

Nucleotide

• Length: 402 bp

>AT55071 NZ_CP011809:86565-86966 [Pandoraea faecigallinarum]
ATGAAATGTCCGGTTTGCGGCGCGGCGGAACTGATCCATGACACCCGCGACCTGCCCTACACCTACAAGGGCGAAACCAC
GATGATTCCTGCGGTGACGGCTGACTTTTGCCCCGCCTGCGATGAGTCCATCACCGACATGGCCGAAACCGAGCGCGTCA
TGGGTGAAATGCAGGCGTTCCACAGACAGGTGAACGCGGCTATCGTTGACCCCGCCTTCATCGTCAAGGTGCGCAAAAAG
CTCGACCTGGGACAGCGTGAGGCCGCCGAAATCTTCGGCGGCGGCATCAATGCCTTCTCGCGTTACGAGAACGGCAAGAC
CAAGCCGCCGCTGGCCCTAGTCAAGCTGTTCAAACTGCTGGATCGGCACCCCGATCTGCTCAACGAAGTTAGAACCGCTT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3X411

Antitoxin

• AlphaFold DB: A0A0H3X0L6