Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 322810..323510 Replicon plasmid pPF72-1
Accession NZ_CP011808
Organism Pandoraea faecigallinarum strain DSM 23572

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0H3X0Q3
Locus tag AB870_RS24560 Protein ID WP_047909401.1
Coordinates 323214..323510 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A0H3X2Q4
Locus tag AB870_RS24555 Protein ID WP_047909400.1
Coordinates 322810..323211 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB870_RS24545 318115..319170 + 1056 WP_047909231.1 IS481 family transposase -
AB870_RS26865 319218..319382 + 165 WP_167362675.1 integrase core domain-containing protein -
AB870_RS24550 319507..322506 - 3000 WP_047909232.1 hypothetical protein -
AB870_RS24555 322810..323211 - 402 WP_047909400.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
AB870_RS24560 323214..323510 - 297 WP_047909401.1 type II toxin-antitoxin system MqsR family toxin Toxin
AB870_RS24565 323620..324685 - 1066 Protein_308 ACR3 family arsenite efflux transporter -
AB870_RS24570 324682..325174 - 493 Protein_309 arsenate reductase ArsC -
AB870_RS24575 325171..325938 - 768 Protein_310 arsenical resistance protein ArsH -
AB870_RS26065 326031..326267 - 237 Protein_311 IS6 family transposase -
AB870_RS24580 326434..327363 + 930 WP_047909234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..386625 386625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10588.35 Da        Isoelectric Point: 7.9141

>T55066 WP_047909401.1 NZ_CP011808:c323510-323214 [Pandoraea faecigallinarum]
VEKPTPHCKLPVGKTFIAAGKVRATHSARLGAAALSLELSDMLAVVRALTPADFFKSMATHADHTVWQDVCRPSTQAGDV
YLKLTVIDDVLIVSFKEL

Download         Length: 297 bp

>T55066 NZ_CP011808:c323510-323214 [Pandoraea faecigallinarum]
GTGGAGAAGCCTACCCCGCATTGCAAGTTGCCTGTAGGCAAAACCTTCATAGCAGCCGGCAAAGTCCGCGCAACCCATTC
GGCCAGGCTTGGGGCCGCTGCCTTGAGTTTGGAGCTCTCCGACATGCTGGCTGTGGTGAGGGCACTCACGCCAGCGGACT
TCTTCAAGAGCATGGCTACCCATGCCGACCACACGGTATGGCAGGACGTGTGCCGCCCCAGCACGCAAGCGGGCGACGTG
TATCTGAAGCTGACGGTCATCGATGACGTGTTGATCGTGTCCTTCAAGGAGCTATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14902.32 Da        Isoelectric Point: 7.2660

>AT55066 WP_047909400.1 NZ_CP011808:c323211-322810 [Pandoraea faecigallinarum]
MKCPVCGAAELIHDTRDLPYTYKGETTMIPALTADFCPACDESITDMAEAERVMREMRAFHRQVNAAIVDPAFIVKVRKK
LDLGQREAAEIFGGGINAFSRYENGKTKPPLALVKLFKLLDRHPDLLHELRTA

Download         Length: 402 bp

>AT55066 NZ_CP011808:c323211-322810 [Pandoraea faecigallinarum]
ATGAAATGTCCGGTTTGCGGCGCGGCGGAACTGATCCATGACACCCGCGACCTGCCCTACACCTACAAGGGCGAAACCAC
GATGATTCCTGCGTTGACGGCTGACTTTTGCCCCGCCTGCGATGAGTCCATCACCGACATGGCCGAAGCCGAGCGCGTCA
TGCGTGAAATGCGGGCGTTCCACAGACAGGTGAACGCGGCTATCGTTGACCCCGCCTTCATCGTCAAGGTGCGCAAAAAG
CTCGACCTGGGACAGCGTGAGGCCGCCGAAATCTTCGGCGGCGGCATCAATGCCTTCTCGCGTTACGAGAACGGCAAGAC
GAAGCCCCCGCTGGCCTTGGTCAAGCTGTTCAAGCTGCTGGATCGGCACCCCGACCTGCTCCACGAGCTCAGAACCGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3X0Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3X2Q4

References