Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 4105828..4106440 Replicon chromosome
Accession NZ_CP011801
Organism Nitrospira moscoviensis strain NSP M-1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NITMOv2_RS20095 Protein ID WP_083448245.1
Coordinates 4106171..4106440 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NITMOv2_RS20090 Protein ID WP_053381552.1
Coordinates 4105828..4106157 (-) Length 110 a.a.

Genomic Context

NITMOv2_RS20070NITMOv2_RS20085NITMOv2_RS23075NITMOv2_RS20075NITMOv2_RS20080NITMOv2_RS20090NITMOv2_RS20095NITMOv2_RS23660NITMOv2_RS20100NITMOv2_RS20105NITMOv2_RS20110NITMOv2_RS20115
Location: 4102124..4103212 (1089 bp)
Type: Others
Protein ID: WP_053381549.1
Location: 4104720..4105724 (1005 bp)
Type: Others
Protein ID: WP_053381551.1
Location: 4101684..4102043 (360 bp)
Type: Others
Protein ID: WP_187299454.1
Location: 4103223..4103576 (354 bp)
Type: Others
Protein ID: WP_083448244.1
Location: 4103573..4103911 (339 bp)
Type: Others
Protein ID: WP_053381550.1
Location: 4105828..4106157 (330 bp)
Type: Antitoxin
Protein ID: WP_053381552.1
Location: 4106171..4106440 (270 bp)
Type: Toxin
Protein ID: WP_083448245.1
Location: 4106436..4106627 (192 bp)
Type: Others
Protein ID: WP_145976449.1
Location: 4106540..4107388 (849 bp)
Type: Others
Protein ID: WP_053381554.1
Location: 4107658..4109520 (1863 bp)
Type: Others
Protein ID: WP_083448247.1
Location: 4109611..4110228 (618 bp)
Type: Others
Protein ID: WP_053381556.1
Location: 4110237..4111382 (1146 bp)
Type: Others
Protein ID: WP_053381557.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NITMOv2_RS230754101684..4102043-360WP_187299454.1hypothetical protein-
NITMOv2_RS200704102124..4103212+1089WP_053381549.1transposase-
NITMOv2_RS200754103223..4103576-354WP_083448244.1helix-turn-helix domain-containing protein-
NITMOv2_RS200804103573..4103911-339WP_053381550.1type II toxin-antitoxin system RelE/ParE family toxin-
NITMOv2_RS200854104720..4105724+1005WP_053381551.1Fic family protein-
NITMOv2_RS200904105828..4106157-330WP_053381552.1HigA family addiction module antidote proteinAntitoxin
NITMOv2_RS200954106171..4106440-270WP_083448245.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NITMOv2_RS236604106436..4106627-192WP_145976449.1aldose 1-epimerase-
NITMOv2_RS201004106540..4107388-849WP_053381554.1hypothetical protein-
NITMOv2_RS201054107658..4109520-1863WP_083448247.1polysaccharide biosynthesis protein-
NITMOv2_RS201104109611..4110228-618WP_053381556.1YdcF family protein-
NITMOv2_RS201154110237..4111382-1146WP_053381557.1DegT/DnrJ/EryC1/StrS family aminotransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--4090399..411022819829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-77)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10219.61 Da        Isoelectric Point: 9.2527

>T55057 WP_083448245.1 NZ_CP011801:c4106440-4106171 [Nitrospira moscoviensis]
ISGRDRRTRLFFAGETIREFSGFKKVAERKLVMLDSASDLKDLGSPGNRLEKLKGNRAGQHSIRINDQWRICFVWMTDGP
HDVEITDDL

Download         Length: 270 bp

>T55057 NZ_CP011801:c4106440-4106171 [Nitrospira moscoviensis]
ATTAGCGGGCGGGACAGGAGAACGAGACTGTTCTTTGCGGGAGAGACGATCAGAGAATTCTCGGGCTTCAAGAAAGTTGC
TGAGCGGAAACTCGTGATGCTCGACAGCGCATCGGATCTGAAAGACCTCGGGTCACCGGGTAACCGGCTTGAGAAGTTGA
AGGGGAATCGAGCCGGGCAGCACAGTATCCGAATTAACGATCAATGGCGGATCTGTTTCGTCTGGATGACAGACGGGCCC
CACGATGTCGAGATTACCGATGACCTCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12077.06 Da        Isoelectric Point: 9.8829

>AT55057 WP_053381552.1 NZ_CP011801:c4106157-4105828 [Nitrospira moscoviensis]
MMKNGMRPVHPGEILLEEFMKPSAPPLNANTLAKALDVPANRITAIIKGQRGITGDTAVRLATFFNTTAEFWMNLQKTYE
LRLAEQALPGRVRKHIEECREALASASSL

Download         Length: 330 bp

>AT55057 NZ_CP011801:c4106157-4105828 [Nitrospira moscoviensis]
ATGATGAAGAACGGCATGCGTCCGGTTCACCCTGGGGAAATTCTGTTGGAAGAGTTTATGAAGCCGTCAGCTCCTCCGCT
TAACGCCAATACACTCGCCAAGGCCCTTGATGTGCCGGCGAATCGGATCACGGCGATTATCAAAGGCCAGCGCGGCATTA
CGGGCGATACGGCAGTGCGGCTGGCTACGTTCTTCAATACGACGGCTGAATTCTGGATGAATCTGCAAAAGACGTATGAG
TTGCGTCTGGCCGAACAAGCCCTGCCGGGCAGGGTGAGGAAGCATATTGAGGAGTGCAGGGAGGCCCTTGCATCGGCGTC
AAGCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References