Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 1630023..1630656 | Replicon | chromosome |
| Accession | NZ_CP011775 | ||
| Organism | Vibrio vulnificus strain FORC_016 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A347UQS4 |
| Locus tag | FORC16_RS07395 | Protein ID | WP_012600340.1 |
| Coordinates | 1630324..1630656 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FORC16_RS07390 | Protein ID | WP_060531655.1 |
| Coordinates | 1630023..1630337 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC16_RS07365 | 1625242..1626210 | + | 969 | WP_081036190.1 | IS30 family transposase | - |
| FORC16_RS22880 | 1626583..1626711 | - | 129 | WP_081036318.1 | DUF3265 domain-containing protein | - |
| FORC16_RS22885 | 1627053..1627181 | - | 129 | WP_155521496.1 | DUF3265 domain-containing protein | - |
| FORC16_RS07370 | 1627178..1627543 | - | 366 | WP_060531662.1 | hypothetical protein | - |
| FORC16_RS07375 | 1627774..1628487 | - | 714 | WP_060531660.1 | hypothetical protein | - |
| FORC16_RS24170 | 1628527..1628604 | - | 78 | WP_108654700.1 | DUF3265 domain-containing protein | - |
| FORC16_RS07380 | 1628643..1628987 | - | 345 | WP_060531659.1 | hypothetical protein | - |
| FORC16_RS22895 | 1629003..1629125 | - | 123 | WP_081036317.1 | DUF3265 domain-containing protein | - |
| FORC16_RS24175 | 1629127..1629879 | - | 753 | WP_060531657.1 | hypothetical protein | - |
| FORC16_RS22905 | 1629916..1630008 | - | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| FORC16_RS07390 | 1630023..1630337 | - | 315 | WP_060531655.1 | DNA-binding transcriptional regulator | Antitoxin |
| FORC16_RS07395 | 1630324..1630656 | - | 333 | WP_012600340.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FORC16_RS22910 | 1630694..1630900 | - | 207 | WP_081036316.1 | DUF3265 domain-containing protein | - |
| FORC16_RS07400 | 1630887..1631147 | - | 261 | WP_060532964.1 | DUF4282 domain-containing protein | - |
| FORC16_RS22915 | 1631325..1631477 | - | 153 | WP_196374722.1 | DUF3265 domain-containing protein | - |
| FORC16_RS07405 | 1631889..1632716 | - | 828 | WP_060531653.1 | restriction endonuclease | - |
| FORC16_RS22920 | 1632701..1632925 | - | 225 | WP_081036232.1 | DUF3265 domain-containing protein | - |
| FORC16_RS07410 | 1632956..1633924 | + | 969 | WP_081036190.1 | IS30 family transposase | - |
| FORC16_RS22925 | 1634208..1634411 | - | 204 | Protein_1431 | hypothetical protein | - |
| FORC16_RS07420 | 1634686..1635228 | + | 543 | WP_060531651.1 | porin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1610914..1786420 | 175506 | |
| - | inside | IScluster/Tn | - | - | 1615680..1626210 | 10530 | |
| - | flank | IS/Tn | - | - | 1632956..1633924 | 968 | |
| - | inside | Integron | - | - | 1617761..1659080 | 41319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12906.76 Da Isoelectric Point: 10.0960
>T55027 WP_012600340.1 NZ_CP011775:c1630656-1630324 [Vibrio vulnificus]
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS
Download Length: 333 bp
>T55027 NZ_CP011775:c1630656-1630324 [Vibrio vulnificus]
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCTGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGTGGTTCTCGCGTTATCTATTACTTCCTCGATGAAAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAGTCGTGA
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCTGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGTGGTTCTCGCGTTATCTATTACTTCCTCGATGAAAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAGTCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11677.15 Da Isoelectric Point: 6.3290
>AT55027 WP_060531655.1 NZ_CP011775:c1630337-1630023 [Vibrio vulnificus]
MSSRDLFAELSSALVEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL
MSSRDLFAELSSALVEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT55027 NZ_CP011775:c1630337-1630023 [Vibrio vulnificus]
ATGAGCAGTCGTGATTTATTTGCAGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAAGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATCAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAGCAATTTAATA
TGTCTCGTGGTGTGTTTGCTCGTTTGTTGCACACGTCATCTCGTACGTTAGAAAACTGGGAGCAAGGGCGTAGCGCACCA
AATGGACAAGCAGTAACCCTTCTAAAGTTGGTTCAGCGTCACCCAGAAACCCTGTCGCACATCGCTGAGCTATAA
ATGAGCAGTCGTGATTTATTTGCAGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAAGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATCAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAGCAATTTAATA
TGTCTCGTGGTGTGTTTGCTCGTTTGTTGCACACGTCATCTCGTACGTTAGAAAACTGGGAGCAAGGGCGTAGCGCACCA
AATGGACAAGCAGTAACCCTTCTAAAGTTGGTTCAGCGTCACCCAGAAACCCTGTCGCACATCGCTGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|