Detailed information of TA system TA055009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2443860..2444515
• Replicon: chromosome
• Accession: NZ_CP011768
• Organism: Bordetella pertussis strain J115

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: ABC61_RS11840
• Protein ID: WP_047122780.1
• Coordinates: 2444264..2444515 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: ABC61_RS11835
• Protein ID: WP_003809516.1
• Coordinates: 2443860..2444261 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABC61_RS11805	2439043..2440065	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
ABC61_RS11810	2440202..2441239	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
ABC61_RS11815	2441259..2442449	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ABC61_RS11820	2442452..2442967	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ABC61_RS11825	2443117..2443596	-	480	WP_010930405.1	disulfide bond formation protein B	-
ABC61_RS11830	2443604..2443840	-	237	WP_010930404.1	membrane protein	-
ABC61_RS11835	2443860..2444261	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ABC61_RS11840	2444264..2444515	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ABC61_RS11845	2444570..2445451	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
ABC61_RS11850	2445676..2446122	+	447	WP_003819827.1	GFA family protein	-
ABC61_RS11855	2446207..2447271	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
ABC61_RS11860	2447408..2447989	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
ABC61_RS11865	2448224..2449354	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T55009 WP_047122780.1 NZ_CP011768:c2444515-2444264 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T55009 NZ_CP011768:c2444515-2444264 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT55009 WP_003809516.1 NZ_CP011768:c2444261-2443860 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT55009 NZ_CP011768:c2444261-2443860 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6