Detailed information of TA system TA054968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2579802..2580457
• Replicon: chromosome
• Accession: NZ_CP011748
• Organism: Bordetella pertussis strain I968

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: ABC41_RS12490
• Protein ID: WP_047122780.1
• Coordinates: 2580206..2580457 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: ABC41_RS12485
• Protein ID: WP_003809516.1
• Coordinates: 2579802..2580203 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABC41_RS12455	2574985..2576007	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
ABC41_RS12460	2576144..2577181	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
ABC41_RS12465	2577201..2578391	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ABC41_RS12470	2578394..2578909	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ABC41_RS12475	2579059..2579538	-	480	WP_010930405.1	disulfide bond formation protein B	-
ABC41_RS12480	2579546..2579782	-	237	WP_010930404.1	membrane protein	-
ABC41_RS12485	2579802..2580203	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ABC41_RS12490	2580206..2580457	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ABC41_RS12495	2580512..2581393	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
ABC41_RS12500	2581618..2582064	+	447	WP_003819827.1	GFA family protein	-
ABC41_RS12505	2582149..2583213	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
ABC41_RS12510	2583350..2583931	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
ABC41_RS12515	2584166..2585296	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T54968 WP_047122780.1 NZ_CP011748:c2580457-2580206 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T54968 NZ_CP011748:c2580457-2580206 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT54968 WP_003809516.1 NZ_CP011748:c2580203-2579802 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT54968 NZ_CP011748:c2580203-2579802 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6