Detailed information of TA system TA054916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1582010..1582665
• Replicon: chromosome
• Accession: NZ_CP011722
• Organism: Bordetella pertussis strain I135

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: ABC15_RS07715
• Protein ID: WP_047122780.1
• Coordinates: 1582010..1582261 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: ABC15_RS07720
• Protein ID: WP_003809516.1
• Coordinates: 1582264..1582665 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABC15_RS07690	1577171..1578301	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
ABC15_RS07695	1578536..1579117	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
ABC15_RS07700	1579254..1580318	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
ABC15_RS07705	1580403..1580849	-	447	WP_003819827.1	GFA family protein	-
ABC15_RS07710	1581074..1581955	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
ABC15_RS07715	1582010..1582261	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ABC15_RS07720	1582264..1582665	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ABC15_RS07725	1582685..1582921	+	237	WP_010930404.1	membrane protein	-
ABC15_RS07730	1582929..1583408	+	480	WP_010930405.1	disulfide bond formation protein B	-
ABC15_RS07735	1583558..1584073	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ABC15_RS07740	1584076..1585266	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ABC15_RS07745	1585286..1586323	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
ABC15_RS07750	1586460..1587482	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T54916 WP_047122780.1 NZ_CP011722:1582010-1582261 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T54916 NZ_CP011722:1582010-1582261 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT54916 WP_003809516.1 NZ_CP011722:1582264-1582665 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT54916 NZ_CP011722:1582264-1582665 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6