Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2534994..2535178 Replicon chromosome
Accession NZ_CP011685
Organism Staphylococcus aureus strain ZJ5499

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag AB179_RS12960 Protein ID WP_000482652.1
Coordinates 2535071..2535178 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2534994..2535054 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB179_RS12935 2530449..2530616 - 168 Protein_2456 hypothetical protein -
AB179_RS12945 2530847..2532580 - 1734 WP_063653200.1 ABC transporter ATP-binding protein/permease -
AB179_RS12950 2532605..2534368 - 1764 WP_063653201.1 ABC transporter ATP-binding protein/permease -
- 2534994..2535054 + 61 - - Antitoxin
AB179_RS12960 2535071..2535178 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
AB179_RS12965 2535312..2535698 - 387 WP_000779360.1 flippase GtxA -
AB179_RS12970 2535966..2537108 + 1143 WP_001176863.1 glycerate kinase -
AB179_RS12975 2537168..2537827 + 660 WP_000831298.1 membrane protein -
AB179_RS12980 2538009..2539220 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
AB179_RS12985 2539343..2539816 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T54841 WP_000482652.1 NZ_CP011685:c2535178-2535071 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T54841 NZ_CP011685:c2535178-2535071 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT54841 NZ_CP011685:2534994-2535054 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References