Detailed information of TA system TA054832

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2064432..2064739
• Replicon: chromosome
• Accession: NZ_CP011685
• Organism: Staphylococcus aureus strain ZJ5499

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AB179_RS14925
• Protein ID: WP_011447039.1
• Coordinates: 2064563..2064739 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2064432..2064571 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB179_RS10370	2059771..2060031	+	261	WP_001791826.1	hypothetical protein	-
AB179_RS10375	2060084..2060434	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AB179_RS10380	2061119..2061568	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AB179_RS15250	2061663..2061998	-	336	Protein_1960	SH3 domain-containing protein	-
AB179_RS10390	2062648..2063139	-	492	WP_000919350.1	staphylokinase	-
AB179_RS10395	2063330..2064085	-	756	WP_000861038.1	CHAP domain-containing protein	-
AB179_RS10400	2064097..2064351	-	255	WP_000611512.1	phage holin	-
AB179_RS10405	2064403..2064510	+	108	WP_001791821.1	hypothetical protein	-
-	2064432..2064571	+	140	NuclAT_0	-	Antitoxin
-	2064432..2064571	+	140	NuclAT_0	-	Antitoxin
-	2064432..2064571	+	140	NuclAT_0	-	Antitoxin
-	2064432..2064571	+	140	NuclAT_0	-	Antitoxin
AB179_RS14925	2064563..2064739	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AB179_RS10410	2064889..2065185	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AB179_RS10415	2065243..2065530	-	288	WP_001040261.1	hypothetical protein	-
AB179_RS10420	2065577..2065729	-	153	WP_001153681.1	hypothetical protein	-
AB179_RS10425	2065719..2069504	-	3786	WP_000582178.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / sell / sec / tsst-1 / groEL	2060084..2126255	66171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T54832 WP_011447039.1 NZ_CP011685:c2064739-2064563 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T54832 NZ_CP011685:c2064739-2064563 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT54832 NZ_CP011685:2064432-2064571 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin