Detailed information of TA system TA054826

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1575160..1575739
• Replicon: chromosome
• Accession: NZ_CP011685
• Organism: Staphylococcus aureus strain ZJ5499

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: AB179_RS07690
• Protein ID: WP_001025401.1
• Coordinates: 1575494..1575739 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1575160..1575525 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB179_RS07650	1571904..1572461	-	558	WP_000645045.1	DUF2815 family protein	-
AB179_RS07655	1572487..1573653	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
AB179_RS07660	1573650..1574012	-	363	WP_000279445.1	hypothetical protein	-
AB179_RS07665	1574027..1574350	-	324	WP_000174995.1	hypothetical protein	-
AB179_RS07670	1574429..1574590	-	162	WP_015986189.1	DUF1270 family protein	-
AB179_RS07675	1574602..1574865	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
AB179_RS07680	1574890..1575105	-	216	WP_001097552.1	hypothetical protein	-
AB179_RS07685	1575160..1575525	+	366	WP_001128433.1	hypothetical protein	Antitoxin
AB179_RS07690	1575494..1575739	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
AB179_RS07695	1575795..1576004	+	210	WP_000642492.1	hypothetical protein	-
AB179_RS07700	1575994..1576137	-	144	WP_000939498.1	hypothetical protein	-
AB179_RS07705	1576152..1576595	-	444	WP_000435360.1	hypothetical protein	-
AB179_RS07710	1576613..1576837	-	225	WP_063653167.1	DUF739 family protein	-
AB179_RS07715	1576999..1577379	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
AB179_RS07720	1577401..1577859	+	459	WP_001558059.1	hypothetical protein	-
AB179_RS07725	1577877..1578198	+	322	Protein_1482	hypothetical protein	-
AB179_RS07730	1578227..1578622	+	396	WP_000449655.1	hypothetical protein	-
AB179_RS07735	1578712..1578858	+	147	WP_001795334.1	hypothetical protein	-
AB179_RS07740	1578855..1579469	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1535468..1598425	62957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T54826 WP_001025401.1 NZ_CP011685:c1575739-1575494 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T54826 NZ_CP011685:c1575739-1575494 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT54826 NZ_CP011685:1575160-1575525 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin