Detailed information of TA system TA054825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1567125..1567539
• Replicon: chromosome
• Accession: NZ_CP011685
• Organism: Staphylococcus aureus strain ZJ5499

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AB179_RS07600
• Protein ID: WP_031267622.1
• Coordinates: 1567288..1567539 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AB179_RS15320
• Protein ID: WP_000028424.1
• Coordinates: 1567125..1567298 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB179_RS07565	1562389..1562679	-	291	WP_000665205.1	VRR-NUC domain-containing protein	-
AB179_RS07570	1562813..1562911	+	99	WP_001801650.1	hypothetical protein	-
AB179_RS07575	1563020..1565467	-	2448	WP_000884870.1	virulence-associated E family protein	-
AB179_RS07580	1565755..1565955	-	201	WP_000265252.1	DUF1514 family protein	-
AB179_RS07585	1566023..1566175	-	153	WP_000595263.1	transcriptional activator RinB	-
AB179_RS07590	1566172..1566378	-	207	WP_000195810.1	DUF1381 domain-containing protein	-
AB179_RS07595	1566415..1566948	-	534	WP_063653166.1	dUTP diphosphatase	-
AB179_RS15315	1566963..1567124	-	162	WP_000889684.1	hypothetical protein	-
AB179_RS15320	1567125..1567298	-	174	WP_000028424.1	hypothetical protein	Antitoxin
AB179_RS07600	1567288..1567539	-	252	WP_031267622.1	DUF1024 family protein	Toxin
AB179_RS07605	1567532..1567839	-	308	Protein_1458	hypothetical protein	-
AB179_RS07610	1567836..1568183	-	348	WP_000979209.1	hypothetical protein	-
AB179_RS07615	1568180..1568560	-	381	WP_001668982.1	hypothetical protein	-
AB179_RS07620	1568563..1568769	-	207	WP_000693989.1	hypothetical protein	-
AB179_RS07625	1568783..1569031	-	249	WP_060474161.1	hypothetical protein	-
AB179_RS07630	1569031..1569285	-	255	WP_000022722.1	DUF3310 domain-containing protein	-
AB179_RS07635	1569282..1569686	-	405	WP_044426014.1	phage DNA polymerase	-
AB179_RS07640	1569686..1569871	-	186	WP_001164629.1	DUF3113 family protein	-
AB179_RS07645	1569884..1571836	-	1953	WP_078064460.1	DNA polymerase	-
AB179_RS07650	1571904..1572461	-	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1535468..1598425	62957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9419.35 Da
• Isoelectric Point: 3.9476

>T54825 WP_031267622.1 NZ_CP011685:c1567539-1567288 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T54825 NZ_CP011685:c1567539-1567288 [Staphylococcus aureus]
ATGAATAATCGCGAAAAAATCGAACAGTCCGTTATTAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT54825 WP_000028424.1 NZ_CP011685:c1567298-1567125 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT54825 NZ_CP011685:c1567298-1567125 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA