Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2996176..2996798 Replicon chromosome
Accession NZ_CP011591
Organism Enterobacter asburiae strain CAV1043

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AB190_RS15795 Protein ID WP_047743221.1
Coordinates 2996176..2996502 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AB190_RS15800 Protein ID WP_074173039.1
Coordinates 2996499..2996798 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB190_RS25375 2993774..2994001 - 228 WP_071845513.1 toxin-antitoxin system HicB family antitoxin -
AB190_RS15785 2994138..2994479 + 342 WP_047743219.1 SymE family type I addiction module toxin -
AB190_RS15790 2995028..2996179 + 1152 WP_040063370.1 IS30 family transposase -
AB190_RS15795 2996176..2996502 + 327 WP_047743221.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AB190_RS15800 2996499..2996798 + 300 WP_074173039.1 XRE family transcriptional regulator Antitoxin
AB190_RS15805 2996828..2997265 - 438 WP_047743222.1 acetyltransferase -
AB190_RS15810 2997397..2998395 - 999 WP_047743224.1 class I SAM-dependent methyltransferase -
AB190_RS15815 2998481..2999419 - 939 WP_047743226.1 helix-turn-helix domain-containing protein -
AB190_RS15820 2999609..3000088 - 480 WP_045354694.1 hypothetical protein -
AB190_RS15825 3000090..3000851 - 762 WP_047743229.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(4-97)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-88)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12590.49 Da        Isoelectric Point: 8.8558

>T54649 WP_047743221.1 NZ_CP011591:2996176-2996502 [Enterobacter asburiae]
MNLQWLFEQEEGLQDKVLADLLNLQHYGPRLPRPYADTVKGSRYKHMKELRIQYAGRPVRAFFAFDPVRQAIVLCAGDKS
NDKTFYEKMIRIADTEFSLHLTSLEATK

Download         Length: 327 bp

>T54649 NZ_CP011591:2996176-2996502 [Enterobacter asburiae]
TTGAATCTACAGTGGTTGTTTGAACAGGAAGAAGGATTACAGGATAAGGTACTGGCAGACCTGCTAAATCTGCAACACTA
TGGGCCACGTCTTCCTCGTCCTTATGCAGATACGGTTAAAGGCTCACGGTATAAACATATGAAAGAATTACGTATTCAAT
ATGCTGGTCGTCCTGTTCGTGCTTTCTTCGCATTTGATCCTGTACGTCAGGCCATTGTGCTTTGCGCGGGCGATAAGAGT
AACGACAAAACCTTTTATGAAAAAATGATTCGCATCGCAGATACCGAATTTTCCCTTCATCTGACAAGCCTGGAGGCAAC
CAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11164.04 Da        Isoelectric Point: 6.9837

>AT54649 WP_074173039.1 NZ_CP011591:2996499-2996798 [Enterobacter asburiae]
VKTLNEMIASRSPDSQQRIKEMAEEMILETGLQLLREELRLSQKNVAELMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp

>AT54649 NZ_CP011591:2996499-2996798 [Enterobacter asburiae]
GTGAAAACCTTAAATGAAATGATTGCGTCACGTTCACCGGATAGCCAACAACGAATTAAAGAAATGGCAGAGGAAATGAT
CCTCGAAACGGGTCTGCAACTTTTACGTGAAGAGCTCAGGCTTTCGCAAAAAAATGTTGCCGAGCTTATGGGGGTAAGCC
AGCCCGCAGTAACTCAGATAGAGCAACGTGGAAATGAACTAAAAATTGCCACACTTAAGCGCTACATTGAGGCAATGGGT
GGGAAACTTTGTATCGACGTTGAACTTCCCACAGGAAAACGCGTTGCATTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References