Detailed information of TA system TA054637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 153154..153814
• Replicon: chromosome
• Accession: NZ_CP011591
• Organism: Enterobacter asburiae strain CAV1043

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AB190_RS02180
• Protein ID: WP_047744331.1
• Coordinates: 153154..153507 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1Z3MX79
• Locus tag: AB190_RS02185
• Protein ID: WP_029741460.1
• Coordinates: 153512..153814 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB190_RS02160	149296..150213	+	918	WP_008499475.1	nitrogen assimilation transcriptional regulator NAC	-
AB190_RS02165	150310..151260	+	951	WP_010432106.1	HTH-type transcriptional regulator Cbl	-
AB190_RS02170	151304..151912	-	609	WP_080470130.1	glutathione S-transferase family protein	-
AB190_RS02175	152083..152976	+	894	WP_047741637.1	LysR family transcriptional regulator	-
AB190_RS02180	153154..153507	+	354	WP_047744331.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AB190_RS02185	153512..153814	+	303	WP_029741460.1	XRE family transcriptional regulator	Antitoxin
AB190_RS02190	153890..154810	-	921	WP_047741638.1	LysR family transcriptional regulator	-
AB190_RS02195	154952..155341	+	390	WP_023312340.1	RidA family protein	-
AB190_RS02205	155665..157854	-	2190	WP_045356712.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-79)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13577.39 Da
• Isoelectric Point: 8.0377

>T54637 WP_047744331.1 NZ_CP011591:153154-153507 [Enterobacter asburiae]
VWAINTTDRFDRWFTSLDDTERASVLAALLVLREKGPGLSRPYADTLKGFRHSNMKELRIQSNGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERE

Nucleotide

• Length: 354 bp

>T54637 NZ_CP011591:153154-153507 [Enterobacter asburiae]
GTGTGGGCAATTAACACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGAACGCGCCAGCGTACTTGC
AGCACTGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTTTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAATGGCGATCCCTTGCGGGCGTTTTTCGCCTTTGATCCAAACCGCACGGGTATC
GTGCTTTGTGCGGGCAATAAGGTCGGCAATGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TCACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11050.83 Da
• Isoelectric Point: 5.7316

>AT54637 WP_029741460.1 NZ_CP011591:153512-153814 [Enterobacter asburiae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT54637 NZ_CP011591:153512-153814 [Enterobacter asburiae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCACCTTGCTGAGTTACGCGAGAAAGTACAAAAAACGCAGGTAGAAATGGCGCAGGCGTTGGGTATCA
GGCAACCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCTCTCAAGCGCTACGTTGAGGCGGCG
GGCGGAAAGCTGCGGCTTGATGTGGAGCTGCCGGATGGCTCGCACTATGAGTTTGTGCTGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1Z3MX79