54591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2709557..2710332 Replicon chromosome
Accession NZ_CP011578
Organism Klebsiella pneumoniae strain CAV1392

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag ABY63_RS14825 Protein ID WP_004150910.1
Coordinates 2709557..2710042 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag ABY63_RS14830 Protein ID WP_004150912.1
Coordinates 2710039..2710332 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABY63_RS14800 2704726..2706093 - 1368 WP_004150905.1 replicative DNA helicase -
ABY63_RS14805 2706086..2706469 - 384 WP_004150906.1 hypothetical protein -
ABY63_RS14810 2706469..2707341 - 873 WP_004188557.1 ParA family protein -
ABY63_RS14815 2707947..2708163 - 217 Protein_2627 transposase -
ABY63_RS14820 2708260..2708853 - 594 WP_004188553.1 hypothetical protein -
ABY63_RS14825 2709557..2710042 - 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
ABY63_RS14830 2710039..2710332 - 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
ABY63_RS14835 2710977..2712353 + 1377 WP_004217775.1 cystathionine beta-synthase -
ABY63_RS14840 2712364..2713512 + 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
ABY63_RS14845 2713513..2714424 - 912 WP_004188550.1 LysR family transcriptional regulator -
ABY63_RS14850 2714522..2715124 + 603 WP_002916735.1 short chain dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 2652535..2710583 58048
flank IS/Tn - - 2708011..2708163 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T54591 WP_004150910.1 NZ_CP011578:c2710042-2709557 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T54591 NZ_CP011578:c2710042-2709557 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT54591 WP_004150912.1 NZ_CP011578:c2710332-2710039 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT54591 NZ_CP011578:c2710332-2710039 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References