Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6224319..6224911 Replicon chromosome
Accession NZ_CP011567
Organism Pseudomonas sp. GR 6-02

Toxin (Protein)


Gene name higB Uniprot ID A0A291AA59
Locus tag PGR6_RS27745 Protein ID WP_026331819.1
Coordinates 6224633..6224911 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A2S8HLP3
Locus tag PGR6_RS27740 Protein ID WP_030129123.1
Coordinates 6224319..6224624 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGR6_RS27710 6219835..6220158 - 324 WP_018927530.1 hypothetical protein -
PGR6_RS27715 6220261..6220686 - 426 WP_064621067.1 secondary thiamine-phosphate synthase enzyme YjbQ -
PGR6_RS27720 6220899..6222236 - 1338 WP_018927528.1 ammonium transporter -
PGR6_RS27725 6222272..6222610 - 339 WP_002555808.1 P-II family nitrogen regulator -
PGR6_RS27730 6223027..6223287 + 261 WP_008076132.1 accessory factor UbiK family protein -
PGR6_RS27735 6223746..6224267 + 522 WP_064621068.1 Bro-N domain-containing protein -
PGR6_RS27740 6224319..6224624 - 306 WP_030129123.1 HigA family addiction module antidote protein Antitoxin
PGR6_RS27745 6224633..6224911 - 279 WP_026331819.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGR6_RS27750 6225161..6225346 + 186 WP_019580492.1 hypothetical protein -
PGR6_RS27755 6225470..6226315 + 846 Protein_5505 ATP-binding protein -
PGR6_RS27760 6226868..6228034 + 1167 WP_064621069.1 three-Cys-motif partner protein TcmP -
PGR6_RS27765 6228285..6229028 + 744 WP_064621368.1 phage Gp37/Gp68 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10550.22 Da        Isoelectric Point: 7.8601

>T54541 WP_026331819.1 NZ_CP011567:c6224911-6224633 [Pseudomonas sp. GR 6-02]
MIVGFKCSETEYLFRNGKTRMWSAILSVVERKLTMLDAAAVLMDLRSPPGNRLEALEGDRKGQHSIRINAQWRICFVWGL
NGPENVEIVDYH

Download         Length: 279 bp

>T54541 NZ_CP011567:c6224911-6224633 [Pseudomonas sp. GR 6-02]
ATGATCGTTGGCTTTAAGTGTTCTGAGACCGAGTACCTGTTTCGCAACGGAAAGACCCGTATGTGGTCAGCCATTCTGAG
TGTCGTGGAACGAAAGCTGACGATGCTTGATGCTGCTGCGGTGCTGATGGACCTTCGATCACCACCAGGCAATCGATTGG
AGGCGCTGGAAGGAGATCGAAAAGGTCAGCACAGCATCCGCATCAACGCTCAATGGCGAATTTGCTTTGTTTGGGGTCTT
AACGGACCAGAGAATGTCGAAATCGTCGATTATCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11244.98 Da        Isoelectric Point: 6.4556

>AT54541 WP_030129123.1 NZ_CP011567:c6224624-6224319 [Pseudomonas sp. GR 6-02]
MTKNGMRPVHPGEILKEEYLEPLSLTAAALARALSVSTPTVNDIVLQRRGVSADMALRLSICLDTTPEFWLNLQSTYDLR
KAEIERGAAIRDQVERLPHCA

Download         Length: 306 bp

>AT54541 NZ_CP011567:c6224624-6224319 [Pseudomonas sp. GR 6-02]
ATGACTAAGAATGGTATGCGCCCGGTTCACCCTGGCGAGATCCTCAAAGAGGAATACCTGGAGCCTCTGAGCCTTACGGC
TGCAGCCTTGGCCAGAGCGTTGAGCGTTTCGACGCCTACGGTGAACGACATCGTACTTCAGCGTCGAGGTGTCAGTGCCG
ATATGGCTCTAAGGCTATCTATCTGCCTGGACACGACTCCCGAGTTTTGGCTGAACCTGCAATCGACATACGATTTGCGA
AAAGCCGAGATCGAACGAGGGGCTGCGATCCGGGATCAGGTTGAGCGGCTCCCGCACTGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291AA59

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8HLP3

References