54500

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1816379..1816893 Replicon chromosome
Accession NZ_CP011536
Organism Lactobacillus fermentum 3872

Toxin (Protein)


Gene name yoeB Uniprot ID A0A806T892
Locus tag N573_RS09150 Protein ID WP_021350110.1
Coordinates 1816379..1816642 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0WV67
Locus tag N573_RS09155 Protein ID WP_003684069.1
Coordinates 1816639..1816893 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N573_RS09135 1811859..1812641 + 783 WP_021350113.1 dimethylargininase -
N573_RS09140 1813029..1814426 + 1398 WP_024271998.1 sodium:proton antiporter -
N573_RS09145 1814852..1815973 + 1122 WP_021350111.1 PTS sugar transporter subunit IIC -
N573_RS09150 1816379..1816642 - 264 WP_021350110.1 Txe/YoeB family addiction module toxin Toxin
N573_RS09155 1816639..1816893 - 255 WP_003684069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N573_RS09160 1817063..1817533 + 471 WP_080965019.1 transposase -
N573_RS09165 1817698..1818606 + 909 WP_080965002.1 IS3 family transposase -
N573_RS09170 1819169..1820521 - 1353 WP_003684067.1 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-55)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10262.99 Da        Isoelectric Point: 10.7050

>T54500 WP_021350110.1 NZ_CP011536:c1816642-1816379 [Lactobacillus fermentum 3872]
MSYAIKLKRSANKDLKKIKGSYLEKSFLQIIEQLRKDPLAPNQGFEKLVPPIKGFYSRRINIQHRLVYKVDQDTQTVIIY
SAWSHNR

Download         Length: 264 bp

>T54500 NZ_CP011536:c1816642-1816379 [Lactobacillus fermentum 3872]
ATGAGTTACGCGATCAAACTTAAGCGGAGCGCTAATAAAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAAAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACCGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATAATAGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9745.04 Da        Isoelectric Point: 4.4237

>AT54500 WP_003684069.1 NZ_CP011536:c1816893-1816639 [Lactobacillus fermentum 3872]
MDQIVTPTQARKDLFKIIKRINENNEPVVIKPTKADEKSVVVIGEDDWKAIQETLFLVNHGVDKQIKERENEPLDDFDDV
WGQL

Download         Length: 255 bp

>AT54500 NZ_CP011536:c1816893-1816639 [Lactobacillus fermentum 3872]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAAGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGACAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806T892

Antitoxin

Source ID Structure
AlphaFold DB A0A806T868

References