Detailed information of TA system TA054492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2451428..2451951
• Replicon: chromosome
• Accession: NZ_CP011528
• Organism: Staphylococcus aureus strain RKI4

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: AA961_RS12485
• Protein ID: WP_047928625.1
• Coordinates: 2451428..2451694 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: AA961_RS12490
• Protein ID: WP_000587618.1
• Coordinates: 2451694..2451951 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA961_RS12465	2446734..2447921	-	1188	WP_047928624.1	MFS transporter	-
AA961_RS12470	2448317..2449093	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
AA961_RS12475	2449086..2449748	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
AA961_RS12480	2449996..2451072	-	1077	WP_001076673.1	M42 family metallopeptidase	-
AA961_RS12485	2451428..2451694	-	267	WP_047928625.1	Txe/YoeB family addiction module toxin	Toxin
AA961_RS12490	2451694..2451951	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AA961_RS12500	2452310..2452765	+	456	WP_000732076.1	DUF1307 domain-containing protein	-
AA961_RS12505	2452933..2454510	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
AA961_RS12510	2454705..2455454	+	750	WP_000072466.1	hypothetical protein	-
AA961_RS12515	2455685..2456878	-	1194	WP_000675407.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10756.59 Da
• Isoelectric Point: 10.3584

>T54492 WP_047928625.1 NZ_CP011528:c2451694-2451428 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LWAWSHYD

Nucleotide

• Length: 267 bp

>T54492 NZ_CP011528:c2451694-2451428 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATGGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT54492 WP_000587618.1 NZ_CP011528:c2451951-2451694 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT54492 NZ_CP011528:c2451951-2451694 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2