Detailed information of TA system TA054490

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2419823..2420007
• Replicon: chromosome
• Accession: NZ_CP011528
• Organism: Staphylococcus aureus strain RKI4

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: AA961_RS15370
• Protein ID: WP_000482647.1
• Coordinates: 2419900..2420007 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2419823..2419883 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA961_RS15350	2415353..2415520	-	168	WP_001790576.1	hypothetical protein	-
AA961_RS12315	2415751..2417484	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
AA961_RS12320	2417509..2419272	-	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
-	2419823..2419883	+	61	-	-	Antitoxin
AA961_RS15370	2419900..2420007	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
AA961_RS12335	2420141..2420527	-	387	WP_000779360.1	flippase GtxA	-
AA961_RS12340	2420785..2421927	+	1143	WP_001176863.1	glycerate kinase	-
AA961_RS12345	2421987..2422646	+	660	WP_000831298.1	membrane protein	-
AA961_RS12350	2422828..2424039	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
AA961_RS12355	2424162..2424635	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T54490 WP_000482647.1 NZ_CP011528:c2420007-2419900 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T54490 NZ_CP011528:c2420007-2419900 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT54490 NZ_CP011528:2419823-2419883 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin