Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2394590..2395107 Replicon chromosome
Accession NZ_CP011528
Organism Staphylococcus aureus strain RKI4

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag AA961_RS12180 Protein ID WP_000113262.1
Coordinates 2394590..2394856 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag AA961_RS12185 Protein ID WP_000584499.1
Coordinates 2394856..2395107 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA961_RS12155 2390018..2390554 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
AA961_RS12160 2390787..2391611 - 825 WP_000572040.1 formate/nitrite transporter family protein -
AA961_RS12165 2391828..2392010 - 183 WP_000230294.1 hypothetical protein -
AA961_RS12170 2392094..2392561 - 468 WP_000153344.1 SRPBCC domain-containing protein -
AA961_RS12175 2392747..2394294 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
AA961_RS12180 2394590..2394856 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
AA961_RS12185 2394856..2395107 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AA961_RS15320 2395272..2395373 - 102 WP_031774922.1 hypothetical protein -
AA961_RS12195 2395380..2395979 - 600 WP_000162813.1 DsbA family protein -
AA961_RS12200 2395998..2396360 - 363 WP_000819843.1 DUF4467 domain-containing protein -
AA961_RS12205 2396615..2397865 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
AA961_RS12210 2397962..2398693 - 732 WP_047928614.1 amino acid ABC transporter ATP-binding protein -
AA961_RS12215 2398690..2399409 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T54489 WP_000113262.1 NZ_CP011528:c2394856-2394590 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T54489 NZ_CP011528:c2394856-2394590 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT54489 WP_000584499.1 NZ_CP011528:c2395107-2394856 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT54489 NZ_CP011528:c2395107-2394856 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References