Detailed information of TA system TA054486

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2140900..2141116
• Replicon: chromosome
• Accession: NZ_CP011528
• Organism: Staphylococcus aureus strain RKI4

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: AA961_RS15175
• Protein ID: WP_001802298.1
• Coordinates: 2141012..2141116 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2140900..2140955 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA961_RS10820	2137094..2137759	-	666	WP_001024095.1	SDR family oxidoreductase	-
AA961_RS10825	2137911..2138231	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
AA961_RS10830	2138233..2139213	+	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
AA961_RS10835	2139479..2140570	+	1092	WP_000495681.1	hypothetical protein	-
-	2140900..2140955	+	56	-	-	Antitoxin
AA961_RS15175	2141012..2141116	-	105	WP_001802298.1	hypothetical protein	Toxin
AA961_RS15780	2141633..2141803	+	171	WP_001792292.1	transposase	-
AA961_RS15185	2141796..2141954	+	159	WP_001792784.1	hypothetical protein	-
AA961_RS10845	2142612..2143469	-	858	WP_047928586.1	Cof-type HAD-IIB family hydrolase	-
AA961_RS10850	2143537..2144319	-	783	WP_000908180.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (24-47)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T54486 WP_001802298.1 NZ_CP011528:c2141116-2141012 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T54486 NZ_CP011528:c2141116-2141012 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT54486 NZ_CP011528:2140900-2140955 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin