Detailed information of TA system TA054481

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1955481..1955788
• Replicon: chromosome
• Accession: NZ_CP011528
• Organism: Staphylococcus aureus strain RKI4

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: AA961_RS15035
• Protein ID: WP_072357969.1
• Coordinates: 1955612..1955788 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1955481..1955620 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA961_RS15005	1950824..1951084	+	261	WP_001791826.1	hypothetical protein	-
AA961_RS09790	1951137..1951487	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
AA961_RS09795	1952170..1952619	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
AA961_RS15010	1952712..1953046	-	335	Protein_1852	SH3 domain-containing protein	-
AA961_RS09805	1953697..1954188	-	492	WP_000920041.1	staphylokinase	-
AA961_RS09810	1954379..1955134	-	756	WP_000861038.1	CHAP domain-containing protein	-
AA961_RS09815	1955146..1955400	-	255	WP_000611512.1	phage holin	-
AA961_RS15030	1955452..1955559	+	108	WP_031762631.1	hypothetical protein	-
-	1955481..1955620	+	140	NuclAT_0	-	Antitoxin
-	1955481..1955620	+	140	NuclAT_0	-	Antitoxin
-	1955481..1955620	+	140	NuclAT_0	-	Antitoxin
-	1955481..1955620	+	140	NuclAT_0	-	Antitoxin
AA961_RS15035	1955612..1955788	-	177	WP_072357969.1	putative holin-like toxin	Toxin
AA961_RS09830	1955931..1956305	-	375	WP_000340977.1	hypothetical protein	-
AA961_RS09835	1956361..1956648	-	288	WP_001262620.1	hypothetical protein	-
AA961_RS15040	1956694..1956846	-	153	WP_001000058.1	hypothetical protein	-
AA961_RS09845	1956839..1960621	-	3783	WP_000582177.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / seb / groEL	1947328..2016409	69081

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T54481 WP_072357969.1 NZ_CP011528:c1955788-1955612 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T54481 NZ_CP011528:c1955788-1955612 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT54481 NZ_CP011528:1955481-1955620 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin