Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2468543..2469066 Replicon chromosome
Accession NZ_CP011526
Organism Staphylococcus aureus strain DSM 20231

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag AA076_RS12600 Protein ID WP_000074048.1
Coordinates 2468543..2468809 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag AA076_RS12605 Protein ID WP_000587616.1
Coordinates 2468809..2469066 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA076_RS12580 2463850..2465037 - 1188 WP_000026194.1 MFS transporter -
AA076_RS12585 2465433..2466209 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
AA076_RS12590 2466202..2466864 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
AA076_RS12595 2467112..2468188 - 1077 WP_001076671.1 M42 family metallopeptidase -
AA076_RS12600 2468543..2468809 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
AA076_RS12605 2468809..2469066 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AA076_RS12615 2469425..2469880 + 456 WP_000732082.1 DUF1307 domain-containing protein -
AA076_RS12620 2470048..2471625 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
AA076_RS12625 2471820..2472569 + 750 WP_000072443.1 hypothetical protein -
AA076_RS12630 2472793..2473986 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T54476 WP_000074048.1 NZ_CP011526:c2468809-2468543 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T54476 NZ_CP011526:c2468809-2468543 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT54476 WP_000587616.1 NZ_CP011526:c2469066-2468809 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT54476 NZ_CP011526:c2469066-2468809 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References