Detailed information of TA system TA054467

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1851598..1851780
• Replicon: chromosome
• Accession: NZ_CP011526
• Organism: Staphylococcus aureus strain DSM 20231

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: AA076_RS15945
• Protein ID: WP_001801861.1
• Coordinates: 1851598..1851693 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1851721..1851780 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AA076_RS09160	1847258..1847884	+	627	WP_000669046.1	hypothetical protein	-
AA076_RS09165	1847925..1848269	+	345	WP_000627551.1	DUF3969 family protein	-
AA076_RS09170	1848367..1848918	+	552	WP_000414205.1	hypothetical protein	-
AA076_RS09175	1849136..1849777	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
AA076_RS09180	1849891..1850076	-	186	WP_000809857.1	hypothetical protein	-
AA076_RS15185	1850078..1850254	-	177	WP_000375476.1	hypothetical protein	-
AA076_RS09190	1850265..1850648	-	384	WP_000070812.1	hypothetical protein	-
AA076_RS15195	1851252..1851395	-	144	WP_001549059.1	transposase	-
AA076_RS15945	1851598..1851693	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1851721..1851780	-	60	-	-	Antitoxin
AA076_RS15200	1851816..1851917	+	102	WP_001791893.1	hypothetical protein	-
AA076_RS15205	1851895..1852071	-	177	Protein_1766	transposase	-
AA076_RS09210	1852265..1852642	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1825571..1884869	59298

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-100)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T54467 WP_001801861.1 NZ_CP011526:1851598-1851693 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T54467 NZ_CP011526:1851598-1851693 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT54467 NZ_CP011526:c1851780-1851721 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin